Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Rebeccamycin analogs

Hussain M, Vaishampayan U, Heilbrun LK, Jain V, LoRusso PM, Ivy P, Flaherty L (2003) A Phase II Study of Rebeccamycin Analog (NSC-655649) in Metastatic Renal Cell Cancer. Invest New Drugs 21 465... [Pg.446]

A wide variety of unique DNA-damaging natural products are in clinical development, including ET-743 derived from a marine tunicate, HMAF (MGl-114) derived from mushrooms, and the bacterium-derived rebeccamycin analog, all of which are nonclassical inhibitors of topoisomerase 11. How natural products achieve this task is unknown. From numerous previous studies, it is very clear that grape seed OPCs show prolific anti-DNA damaging activity in normal cells and promote DNA-damaging activity in cancerous cells. Future studies will umavel the underlying mechanisms. [Pg.400]

Using the same enzyme, a library of antitumor indolocarbazoles was generated in a combinatorial fashion in vivo upon halogenation and glycosylation, producing halogenated analogs of rebeccamycin (Scheme 7.14) [54]. [Pg.148]

See other pages where Rebeccamycin analogs is mentioned: [Pg.314]    [Pg.218]    [Pg.21]    [Pg.21]    [Pg.21]    [Pg.22]    [Pg.699]    [Pg.314]    [Pg.218]    [Pg.21]    [Pg.21]    [Pg.21]    [Pg.22]    [Pg.699]    [Pg.187]    [Pg.351]    [Pg.130]    [Pg.217]    [Pg.135]    [Pg.162]    [Pg.63]    [Pg.28]    [Pg.2628]    [Pg.442]    [Pg.451]    [Pg.184]    [Pg.367]    [Pg.16]    [Pg.31]    [Pg.449]   


SEARCH



Indolocarbazoles rebeccamycin analogs

© 2024 chempedia.info