Reactivity of Platinum Metal—Base Complexes

The preceding discussion has emphasized studies of binding sites and thermodynamic/kinetic considerations. An area of interest, which is now receiving as much attention as the structural aspects, is the reactivity of the bases upon metallation. The principal points of nucleobase chemistry modified by metallation which have been studied are  

These points all refer to alteration of the inherent chemistry of the bases, which, although not emphasized in relation to platinum metal complexes and their antitumour activity, is a recognized lesion which may lead to cell kill through inhibition of DNA synthesis. Further features of metal—nucleobase chemistry are the dynamic features of 

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