Reactive intermediates in organic chemistry

For general references, see Isaacs, N.S. Reactive Intermediates in Organic Chemistry, Wiley NY, 1974, McManus, S.P. Organic Reactive Intermediates, Academic Press NY, 1973. Two serial publications devoted to review articles on this subject are Reactive Intermediates (Wiley) and Reactive Intermediates (Plenum). 

Isaacs, n. s. Reactive Intermediates in Organic Chemistry (Wiley, 1974). 

Davies AG, Roberts BP (1973) In Kochi JK (ed) Free Radicals (Reactive Intermediates in Organic Chemistry), vol 1. WUey, New York, p 547... 

N.S.Isaacs, in "Reactive Intermediates in Organic Chemistry", John Wiley and Sons (Eds.), London, 1974, pp.334-335. 

The behavior of the S-hexenyl radical merits special attention not only because it is one of the best understood reactive intermediates in organic chemistry, but also because it is a representative parent of a larger class of cyclizations. Because it is a cyclization of intermediate rate, it provides a convenient (if arbitrary) dividing point for synthetic planning cyclizations that are more rapid than that of the hexenyl radical are easily conducted, but those that are significantly slower may present experimental difficulties. 

Carbocations are one of the most important types of reactive intermediates in organic chemistry. They are encountered in many reactions in addition to the SN1 reaction. 

Thus, homolysis and heterolysis generate radicals, carbocations. and carbanions, the three most important reactive intermediates in organic chemistry. 

Wentrup, C. Reactive Molecules the Neutral Reactives Intermediates in Organic chemistry, Wiley New York, 1984. 

T. L. Gilchrist and C. W. Rees, Carbenes, Nitrenes, and Arynes, Chapter 8. Nelson, London, 1969 H. Heaney, Essays Chem. 1,95 (1970) N. S. Isaacs, Reactive Intermediates in Organic Chemistry, Chapter 7. Wiley, New York, 1974. 

Shevlin, P. B. In Reactive Intermediates in Organic Chemistry Abramo-vitch, R., Ed. Plenum New York, in press. 

A new kind of reactive intermediate in organic chemistry. Also, a summary of nucleophilic displacement reactions. 

The displacement of one chloro group in carbonimidoyl dichlorides by alkoxide, phenoxide, or thiolate ion is the best general method of synthesis of 1-haloformimidates or 1-halothioformimidates. However, several other methods of synthesis are available and since nucleophilic displacement of the halo group is easily accomplished, further utilization of these reactive intermediates in organic chemistry is anticipated. 

Reactive Intermediates in Organic Chemistry Structure, Mechanism, and Reactions, First Edition. 

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