Reactions of Nucleophiles with sp3 Hybridised Carbon Centres

4 Reactions of Nucleophiles with sp3 Hybridised Carbon Centres 

This type of reaction is related to the well-known SN2 reaction, widely encountered in organic chemistry. The essential feature of this type of a reaction is the presence of a leaving group attached to the sp3 carbon centre. The reactions may be controlled in a number of ways. The metal could either co-ordinate to the leaving group and stabilise the anionic species as it is formed, or it could co-ordinate to some other group and increase the S+ charge on the sp3 carbon atom and hence activate it towards the initial attack by the nucleophile (Fig. 4-36). 

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