Reaction rational

ELECTROPHOBIC, ELECTROPHILIC, VOLCANO AND INVERTED VOLCANO REACTIONS RATIONALIZATION, RULES, AND PREDICTIONS... 

One of the most intriguing features of olefin metathesis, and an aspect which continues to receive increasing attention, is the stereochemistry of the reaction. Rationalizations of stereochemical peculiarities have undergone a metamorphosis which parallels advances of mechanistic theories from the pairwise scrambling schemes to the now-popular car-bene-to-metallocycle scheme. As yet there exists no unified stereochemical model which can adequately account for all the observed results. 

After washing with acetonitrile (1 mL, 6 times), the resins were washed with a saturated aqueous solution of sodium bicarbonate (200 pL), and then washed with water (more than 6 times) see Note 10). The Ninhydrin test is useful for estimation of the reaction ration. 

Although derivatives of (8) are formed in many different reactions, rational syntheses usually begin with trihalocarbons and Co2(CO)s as reagents. Bromoform gives the hydrocarbon [CosCJH, whereas CCLt yields [Co3C]Cl. ... 

Allemann C, Gordillo R, Clemente FR, Cheong PH-Y, Houk KN. Theory of asymmetric organocatalysis of aldol and related reactions rationalizations and predictions. Acc. Chem. Res. 2004 37 558-569. 

Theory of Asymmetric Organocatalysis of Aldol and Related Reactions Rationalizations and Predictions Allemann, C. Gordillo, R. Clemente, F.R. Cheong, P.H.-Y. Houk.K.N. Acc. Chem.Res. 2004,37,558. 

In some cases, kinetic data readily distinguish between outer-and inner-sphere mechanisms, but in many reactions, rationalizing the data in terms of a mechanism is not straightforward. 

Key words Affinity, Biomimetic ligands, Combinatorial synthesis. Protein pirtification. Multi-component reaction, Rational design, Ugi reaction... 

---