Reaction Optimization and Library Generation - A Case Study

Consequently, which strategy is utilized in reaction optimization experiments is highly dependent on the type of instrument used. Whilst multimode reactors employ powerful magnetrons with up to 1500 W microwave output power, monomode reactors apply a maximum of only 300 W. This is due to the high density microwave field in a single-mode set-up and the smaller sample volumes that need to be heated. In principle, it is possible to translate optimized protocols from monomode to multimode instruments and to increase the scale by a factor of 100 without a loss of efficiency (see Section 4.5). 

As a starting point for reaction optimization, Biotage offers a microwave reaction database (Emrys PathFinder) with ca. 4000 validated entries for microwave chemistry performed with Biotage single-mode instruments. 

Reaction Optimization and Library Generation - A Case Study 

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