Reactions of Carbon Nucleophiles with Carbonyl Groups

Reaction of Carbon Nucleophiles with Carbonyl Groups 

The reactions described in this chapter include some of the most useful synthetic methods for carbon-carbon bond formation the aldol and Claisen condensations, the Robinson annulation, and the Wittig reaction and related olefination methods. All of these reactions begin by the addition of a carbon nucleophile to a carbonyl group. The product which is isolated depends on the nature of the substituent (X) on the carbon nucleophile, the substituents (A and B) on the carbonyl group, and the ways in which A, B, and X interact to control the reaction pathways available to the addition intermediate. 

The fundamental mechanistic concepts underlying these reactions were introduced in Chapter 8 of Part A. Here we will explore the scope and synthetic utility of these reactions. 

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Chapter 2. Reactions of Carbon Nucleophiles with Carbonyl Groups... 

CHAPTER 2 REACTIONS OF CARBON NUCLEOPHILES WITH CARBONYL GROUPS... 

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