Rate, dosage regimens

Renal function impairment W th renal impairment, relative overdose might occur even with a standard dosage regimen. In patients with marked renal insufficiency (creatinine clearance less than 15 mL/min) and on hemodialysis, elimination half-lives are prolonged 2 days or less. Reduce the bolus dose and rate of infusion in patients with known or suspected renal insufficiency (see Administration and Dosage). 

Compliance Poor compliance with the dosage regimen, particularly daily administered nonrifamycin drugs in the intensive phase, was associated with late sputum conversion and a high relapse rate. 

Indicates the rate at which the drug would be eliminated from the body affects the overall half-life of the drug Essential for determining useful and effective dosage regimens for drugs ideally would allow for once-daily dosing... 

The safety of gadobenate dimeglumine has been confirmed in phase 2 and phase 3 studies in Japan (10,11). The overall adverse reaction rate was 3.5-5% and all the reactions were mild or moderate. There were no differences in the rates of adverse reactions with different dosage regimens (0.05-2.0 mmol/kg). 

The variety of methods that may be used to estimate the rate of drug absorption shows the uncertainty associated with determining this component of bioavailability. Fortunately, the extent of absorption (systemic availability), in conjunction with the peak plasma concentration and apparent half-life, is of greater interest in designing drug dosage regimens. 

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