Dosage regimen infusion rate

Renal function impairment W th renal impairment, relative overdose might occur even with a standard dosage regimen. In patients with marked renal insufficiency (creatinine clearance less than 15 mL/min) and on hemodialysis, elimination half-lives are prolonged 2 days or less. Reduce the bolus dose and rate of infusion in patients with known or suspected renal insufficiency (see Administration and Dosage). 

Chiou, W. L., Gadalla, M. A., and Peng, G. W., Method for the rapid estimation of the total body drug clearance and adjustment of dosage regimens in patients during a constant-rate intravenous infusion, J. Pharmacokinet. Biopharm., 6(2) 135-151, 1978. 

Drug dosage regimen Rapid push administration of 3-20 ml was associated with a similar adverse reaction rate as infusion by pump over 2 hours, in which mild transient local reactions were reported most frequently [49 ]. 

Drug dosage regimens It has been recommended that standard-rate infusions should be used for the initial management of diabetic ketoacidosis. Low-dose intravenous insulin 0.05 units/kg/hour ( = 41) has been compared with 0.1 units/kg/hour ( = 52) in children, mean age 8 years [10 ]. The low-dose infusion appeared to be as effective in treating diabetic ketoacidosis and may have had some beneficial effects on Glasgow Coma Scores, but the number of subjects was small. 

Amiodarone adsorbs to polyvinyl chloride (PVC) tubing, and the clinical trial dose administration schedule was designed to account for this adsorption. Clinical trials were conducted using PVC tubing therefore its use is recommended. The concentrations and rates of infusion provided in Administration and Dosage reflect doses identified in these studies. It is important that the recommended infusion regimen be followed closely. 

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