RAR-y and RXR-a Retinoid Complexes

The structure of atRA bound to RAR-y was one of the first reported structures of the ligand-binding domain of an NHR bound to a ligand (PDB entry 2LBD) [25, 

Structure of the protein result in changes in the relative positions of the helices. These changes alter the size and shape of the binding pockets to better accommodate the appropriate ligands. Clearly different NHRs have evolved structures that are complementary to their respective ligands. 

(b) Superposition of atRA (black) and 9cRA (gray) bound to RAR-y. 

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