RARs

The primary endogenous ligand for RARs is trans- Js. RA is the endogenous ligand for RXRs. Rol3-7410 (278) and Ro 41-5253 (279) are... 

Uranium cost category, /kg RAR T> Resource category EAR SR Total... 

Reasonably Assured Resources (RAR) refers to uranium in known mineral deposits of size, grade, and configuration such that recovery is within the given production cost ranges with currentiy proven mining and processing technology. The majority of these resources are found in AustraUa, Brazil,... 

The specific role of vitamin A in tissue differentiation has been an active area of research. The current thinking, developed in 1979, involves initial dehvery of retinol by holo-B >V (retinol-binding protein) to the cell cytosol (66). Retinol is then ultimately oxidized to retinoic acid and binds to a specific cellular retinoid-binding protein and is transported to the nucleus. Retinoic acid is then transferred to a nuclear retinoic acid receptor (RAR), which enhances the expression of a specific region of the genome. Transcription occurs and new proteins appear during the retinoic acid-induced differentiation of cells (56). 

Figure 10.12 Response elements for heterodimers of the nuclear receptor for ds-retinoic acid (RXR) with the receptors for vitamin D (VDR), thyroid hormone (TR) and trans-retinoic acid (RAR). The half-sites of these response elements have identical nucleotide sequences and are organized as direct repeats. They differ in the number of base pairs in the spacer region between the half-sites. This difference forms the basis for the ability of the heterodimers to discriminate between the different response elements.

National Transportation Safety Board. 1972. Railroad Accident Report—Derailment of Toledo, Peoria and Western Railroad Company s Train No. 20 with Resultant Fire and Tank Car Ruptures, Crescent City, Illinois, June 21, 1970. NTSB-RAR-72-2. 

National Transportation Safety Board. 1973. Railroad Accident Report—Hazardous materials railroad accident in the Alton and Southern Gateway Yard in East St. Louis, Dlinois, January 22, 1972. NTSB-RAR-73-1. 

National Transportation Safety Board. 1975. Hazardous materials accident in the railroad yard of the Norfolk and Western Railway, Decatur, Illinois, July 19, 1974. Report No. NTSB-RAR-75-4. National Transportation Safety Board, Washington, DC. 

ELECTRICAL EQUIPMENT 1.2 Po rar Conditioning and Proioetlon Oavieas APPENDIX A - CCPS TAXONOMY ... 

In ancient literaiure ilicrti app-rar inanv references to cinnamon, but as these do not appear lo Qieaii the ciunaniou hark as we know it to-day, and the latter is so largely a British product, the following in-terestinc details, due to K. M. Holnies, may be quoted —... 

T rada Name Manufactu rar Country Year Introducad... 

Trada Namas Manufactu rar Country Yaar Introduced... 

The addition of the anion of the 1,3-dimethyl-2-butenyl sulfoxides to 2-cyclopentenone was examined2. The anion of rar-2-methyl-4-(phenylsulfinyl)-2-pentene gave a 50 50 mixture of ( )- and (Z)-y-1,4-adducts which differed in the relative configuration of the new stereocenter regarding the stereocenter at sulfur. That is, for either the (Z)- or the ( )-product there is complete asymmetric induction from the stereocenter at sulfur, but in the opposite direction. When the rm-butyl analog, ruc-4-(/wt-butylsulfinyl)-2-methyl-2-pcntcne, was reacted, it gave exclusively the ( )-adduct, likewise as a single diastereomer. 

---