Rapp Polymere

Polystyrene A OH Loading 1.15 mmol/g 200-400 mesh. Rapp polymere Cat. HA 1 400 00 Batch 400s69. 

Ernst-Simon Strasse 9 D 72072 Tubingen, Germany (49)7071-763157 FAX (49) 7071-763158 http //www.rapp-polymere.com... 

All starting materials were obtained from Aldrich (Milwaukee, WI). TentaGel resin was obtained from Rapp Polymere (Tubingen, Germany). Procedures for the synthesis of the PFS linker and its attachment to resin to form 13 have been previous described.3... 

Resins for solid-support synthesis can be obtained from Rapp-Polymere (Germany), Novabiochem (USA), Advanced ChemTech (USA), Chemlmpex, and other suppliers. 

Solid phase supports are from Rapp Polymere GmbH (Germany). The substitution levels of supports used in this laboratory are in the range 0.15-0.4 mmol/g. 

Aminomethylated polystyrene resin was obtained from Rapp Polymere GmbH, Germany. 

This is a composite of 1 % cross-linked polystyrene and covalently attached polyethylene glycol (PEG) (2000-3000 Da). One form, sold under the name TentaGel (Rapp Polymere), is made by polymerizing ethylene oxide on to a primary alcohol located on the cross-linked polystyrene [22,23], A second form, sold under the name PEG-PS (Perseptive), is made by attaching, through the formation of an amide bond, an already formed amino terminal PEG chain (Jeffamine) to 1% cross-linked polystyrene [24], The loading capacities for both types of supports are typically in the range of 0.2-0.3 mmol amine/g resin. 

Available from RAPP Polymere GmbH, Ernst-Simon-Strasse 9, D-72072 Tuebingen, Germany. 

Mettler Toledo MiniBlock Multisyntech MicroBlock Rapp Polymere SYREM... 

Chemspeed SmartStart Heidolph Synthesis 1 Rapp Polymere APOS 1200... 

The synthesis of highly substituted pyrrolidines was performed using commercially available monodisperse polystyrene Wang resin from Rapp Polymere (Tubingen, Germany). The diameter of the beads was 160 pm. 

Rapp Polymere GmbH [79] has designed the APOS 1200 synthesizer (Fig. 31) for solid-phase parallel synthesis. This has 12 cylindrical glass reaction vessels, each of which has a... 

Figure 31. APOS 1200 synthesizer (Rapp Polymere GmbH).

Rapp Polymere GmbH, Emst-Simon-Str. 9, D 72072 Tubingen, Germany. Schleicher and Schuell... 

Resin TentaGel S-NH2 resin, 0.29 mmol/g, 180-220 im (Rapp Polymere GmbH, Tubingen, Germany). 

While polystyrene is an inexpensive resin that has been used widely, especially in Boc-SPPS and in Fmoc-SPPS of shorter sequences, other resins provide certain advantages. An important class of resins is constructed from a polystyrene core onto which PEG chains have been attached. TentaGel (Rapp Polymere, Germany) carries amino groups at the end of the PEG chains. It is important to realize that these polystyrene microparticles have been functionalized with PEG inside out, thus not only on the surface of the resin bead. These supports often provide higher purity of synthesized peptide, especially with longer sequences and with peptides that are prone to aggregate. 

TentaGel resins sold as standard grade (S) loading approx. 0.25 or research grade (R) loading approx. 0.15 mmol/g from Rapp Polymere. 

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