Range of Chemicals That Cause Endocrine Disruption

2 Range of Chemicals that Cause Endocrine Disruption 

Materials other than the PCBs and dioxins described above have been found or are suspected to have estrogenic activity. Table 5.5 lists some of these compounds in addition to those already presented. Many of these compounds are derived from industrial sources including surfactants, degradation of fire retardants, plasticizers, insecticides, or are natural products released in waste streams. 

Stacking by 2,3,7,8 dioxin and PCBs. Note that the 2.2, 4,4, 6,6 HCB does not effectively interact with the Porphine ring system. 

Suggested mode of action of a PCB with a substituted -OH group. 

As in the case with the estrogenic PCBs, the ability to mimic estrogen is an important structural key. The next paragraphs compare some of the estrogenic acting compounds to estradiol. 

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