Raney nickle

The above hydrochloride is treated with thionyl chloride in liquid sulfur dioxide, to produce an amorphous chloride hydro chloride, which is converted to the nitrile with sodium cyanide in liquid hydrogen cyanide, Methanolysis then gives the ester of the nitrile. Alkaline hydrolysis of this last compound, followed by catalytic dehydrogenation in water using a deactivated Raney Nickle catalyst (see JOC, 13, 455 1948) gives dl-lysergic acid. 

Reduction of the Above Hydrogenated Product. The above product is reduced by using Raney Nickle as instructed in the reductions chapter. The resulting product is then demethylated as described in some of the formulas to follow. 

To reduce 3-indoyl-acetone to the active product with LiAlH4, just replace the above intermediate 2 with 3-indoyl-acetone and proceed as described. Many of the reductions (Raney Nickle, zinc, etc.) listed in the reductions chapter may also work. 

RADICAL ANION ARYLATION, 58, 134 Raney nickle, 57, 19, 58, 114, 116 Raney nickel,W-2, 56, 16, 74 Reduction, carboxyl groups, 56,83 Reductive alkylation, 56, 52 Resolution of amines, 55, 80, 83 Rexyn 201, 55,4 Rhodium(III) oxide, 57,1 Ring contraction, 56. 107... 

JA29). The same product was obtained by Stetter and Spangenberger by Raney nickle-catalyzed hydrogenation of 56 (R = R1 = H) (58CB1982). 

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