Random phase detection

Fig. 10 Two-dimensional /1//2 cross-sections from four-dimensional N.C-NOESY data for the DHl domain of Kalirin. One dimensional cross sections parallel to the/i axis at the f2 frequencies indicated by the colored lines are shown above each panel. Panel A is the real/real component of the two dimensional DPT spectrum using quadrature detection in all dimensions. Panel B is the DPT spectrum obtained using only the real/real/real component from the three indirect time dimensions of the time domain data. Panel C is the maximum entropy spectrum obtained using random phase detection. Panels B and C employ l/8th the number of samples used in panel A...

Closs G L and Miller R J 1979 Laser flash photolysis with NMR detection. Microsecond time-resolved CIDNP separation of geminate and random-phase polarization J. Am. Chem. Soc. 101 1639—41... 

Clozapine and risperidone have been compared in a randomized, open study in patients with schizophrenia for 10 weeks treatment outcomes were assessed blindly and 19 patients entered the randomized phase (78). There were no significant differences between the groups in baseline or end-point positive or negative symptoms, disease severity, or global or social functioning scores, and patients opinion on the two drugs did not differ. These results have corroborated previous evidence that risperidone may be as effective as clozapine, but it is probable that this study does not have enough power to detect a difference. 

Two papers have been presented on the photochemistry of 5-methylphena-zinium salts in aqueous solution. Fluorescence, optical flash photolysis, and electron paramagnetic resonance (e.p.r.) techniques have been used to elucidate various aspects of product formation and quantum yield. Two products have been identified, namely the 5-methyl-10-hydrophenazinium cation radical (MPH ) and the pyocyanine (l-hydroxy-5-methyl-phenozinium) cation (PyH ) in a stoicheiometric ratio of 2 1. The quantum yield of formation of (MPH ) was found to be 0.29 0.03 at pH 7.0 and 1.1 0.1 at pH 3.0. The triplet state of MP (Ti) has also been detected by triplet-triplet absorption and is found to have a lifetime of 0.5 ns. Flash photolysis and e.p.r. have also been used to study a geminate triplet radical pair obtained from hydrogen abstraction by excited triplet acetone from propan-2-ol. The authors demonstrate that the geminate pairs contribute most of the polarization in photochemically-induced dynamic electron polarization (CIDEP) as compared with free random-phase pairs. 

According to Internet survey, three randomized trials in untreated stage IIIB/IV patients with NSCLC regarding a nitric oxide-donating drug, nitroglycerin, have been detected. Of the three trials, one randomized trial had been completed and two randomized trials have been performed in Japan and in Australia. Furthermore, a randomized phase I in patients at high risk of colorectal cancer has been completed. 

We can detect a randomized phase III trial of adding nitroglycerin to first-line chemotherapy in patients with advanced NSCLC performed by Dr. M. Boyer at the University of Sydney by Internet (Boyer et al.). However, the details of the trial are not available. 

Yet, it is reasonable to suppose that water molecules from the liquid are still evaporating, even at equilibrium. Molecules in the liquid have no way of knowing that the partial pressure of the vapor is equal to the vapor pressure. In the gas phase, the randomly moving molecules continue to strike the surface of the liquid and condense. Equilibrium corresponds to a perfect balance between this continuing evaporation and condensation. Then no net changes can be detected. ... 

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