Radiosensitization clinical indications

Role of p53 in 5-FU-Induced Radiosensitization Role of 5-FU Radiosensitization in Gene Therapy Oral Forms of 5-FU Capecitabine (Xeloda) in Combination with Radiation Therapy Clinical Indications... 

It should be noted that the compound alone has no therapeutic effect in malignant tumours. Cases of inoperable carcinoma of the bronchus have been treated2 by a combination of X-ray therapy and compound (VIII). In such cases and also in connexion with malignant tumours of other types, there are indications from preliminary clinical studies, that the intravenous administration of compound (VIII) has a small but useful effect as a clinical radiosensitizer. 

Fast neutrons were the first nonconventional radiation used in cancer therapy. Fast neutrons (a high-LET radiation) were introduced for the following radiobiological reasons (1) a reduction of the OER with increasing LET (2) a reduction in the difference in radiosensitivity related to the position of the cells in the mitotic cycle (3) and less repair and thus less clinical relevance of the different repair mechanisms. The best and clinically proven indications for fast neutrons are salivary gland tumors, locally advanced prostatic adenocarcinomas, and slowly growing, well-differentiated sarcomas. 

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