Radiopharmaceuticals gallium

The gallium and indium complexes of novel bis(thiosemicarbazones) have been investigated.71-73 Initial publications indicated a more complex stoichiometry where X-ray crystal structures suggested either dinuclear or trinuclear complexes. Whereas these complexes are quite interesting, they are less likely to result in useful nuclear medicine radiopharmaceuticals. The bis(thiosemi-carbazones) are quite useful as ligands for copper, and are discussed in more detail vide infra). 

Radiopharmaceuticals are also formed from radionuclides of gallium(III),indium(III) and a few other polyvalent cations. The applications of these species are discussed in subsequent sections. 

Wang, S., Lee, R. J Mathias, C. J., Green, M. A., and Low, P. S. (1996) Synthesis, purification, and tumor cell uptake of Gallium-67-deferoxamine-folate, a potential radiopharmaceutical for tumor imaging. Bioconj. Chem. 7, 56-62. 

Moerlein SM and Welch MJ (1981) The chemistry of gallium and indium as related to radiopharmaceutical production. Int J Nucl Med Biol 8 277-287. 

Moerlein SM, Welch MJ, Raymond KN and Weitl FL (1981) Tricatecholamide analogs of enterobactin as gallium- and indium-binding radiopharmaceuticals. J Nucl Med 22 710-719. 

This imaging radiopharmaceutical, in the form of its eitrate, is eoneentrated in some tumours of the lymphatie system and other soft tissues. Loealization has been reported in inflammatory lesions and Gallium-67 has been employed effectively for the diagnosis of infeetion. 

The coordination chemistry of gallium and indium has been reviewed in Chapters 25.1 and 25.2. Other reviews relating specifically to radiopharmaceutical applications have been provided by Thakur, more recently by Moerlein and Welch and, in the case of indium, by Kaempfer. ... 

Smith-Jones P M, Stolz B, Bruns C, et al. (1994). Gallium-67/gallium-68-[DFO]-octreotide-a potential radiopharmaceutical for PET imaging of somatostatin receptorpositive tumors Synthesis and radiolabeling in vitro and preliminary in vivo studies. J. Nucl. Med. 35 317-325. 

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