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Radioligand-displacement binding assay

Neonicotinoids do not act as a homogenous class of insecticides. Radioligand receptor binding assays revealed two classes of neonicotinoids described here as competitive and non-competitive , respectively, relative to [ H]imidacloprid. Differences in affinity, mode of displacement, number of binding sites and temperature sensitivity suggest that thiamethoxam binds in a way unique among the commercial neonicotinoids. Metabolic transformation is not relevant for its insecticidal effects. [Pg.67]

A more detailed pharmacoprofiling of DS-96, which included a CEREP profile for off-target receptor binding (radioligand displacement assays), abbreviated... [Pg.275]

K The measure of displacing potency of a ligand in radioligand-binding assay under appropriate conditions, equals K[>. It is commonly estimated from the IC50. using the Cheng-PrusofT equation. [Pg.320]

Binding assays are based on the displacement of radioligand hERG inhibitors, such as [3H] dofetilide [8-13] and [3H] astem-izole [14], which are bound to hERG channel-expressing cells [HEK293 or Chinese hamster ovary (CHO)] or ventricular myocytes, by the test compounds. [Pg.48]

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See also in sourсe #XX -- [ Pg.228 ]



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Binding assays

Displacement assay

Displacement binding

Radioligand

Radioligand assay

Radioligand binding assay

Radioligands

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