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Radiolabeled annexin V analogs

Table 13.2 Climcal Imaging Studies Using Radiolabeled Annexin V Analogs... Table 13.2 Climcal Imaging Studies Using Radiolabeled Annexin V Analogs...
A recent study presented data indicating that it is possible to improve the plasma clearance kinetics of radiolabeled annexin V analogs by treatment of the protein with polyethylene glycol (PEG) (37). Previous studies have shown that PEG-modified proteins exhibit a reduced liver uptake, increased blood circulating half-lives, and an improved signal-to-noise ratio for imaging purposes. In this study, which used In-DTPA-PEG-annexin V, the fast component of plasma clearance (ti/2, a) in nude mice was 4.9 h compared with 4.2 min for the nonPEGylated annexin V. The In-DTPA-PEG-annexin V had a much... [Pg.338]

The relatively long biological half-hfe of radiolabeled annexin V analogs and prolonged time between i.v. administration of the radiotracer and imaging... [Pg.339]

See other pages where Radiolabeled annexin V analogs is mentioned: [Pg.327]    [Pg.336]    [Pg.336]    [Pg.327]    [Pg.336]    [Pg.336]   
See also in sourсe #XX -- [ Pg.336 , Pg.337 , Pg.338 , Pg.339 , Pg.340 , Pg.341 , Pg.342 , Pg.343 ]



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Annexins

Radiolabeling

Radiolabeling/radiolabeled

Radiolabelling

Radiolabels

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