Radianthus paumotensis

Schweitz et al. purified four related toxins (Rpl, RpII, RpIII, and RpIV) from sea anemone Radianthus paumotensis (Rp) and studied their pharmacological properties (9). During the course of initial NMR studies, the reported sequence of RpII was found to have errors, and was redetermined (8). Subsequently Metrione et al. determined the sequence of RpIII as well (10). T e other two Rp toxin sequences are yet to be determined. Sequences of the Rp, and several other sea anemone toxins, are shown in Table I. We have used a two letter code to denote the species consistently and this notation differs from the earlier designations of Norton and Wiithrich groups. In our notation. As la and Ax I correspond to ATX la and AP-A, respectively. From alignment of the cystines in these sequences, it is clear that Rp toxins have three disulfide bonds, as do the other toxins. 

Radianthus paumotensis II (RP II) Radianthus paumotensis III (RP IE) Radianthus macrodactylus III (RM El) Anemonia sulcata la (AS la) Anemonia sulcata Ib (AS Ib) Anemonia sulcata II (AS II)... 

Heteractis crispa Stichodactyla helianthus Radianthus paumotensis... 

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