Rabbits endocytosis

M. G. Qaddoumi, H. J. Gukasyan, J. Davda, V. Labhasetwar, K. J. Kim, and V. H. Lee. Clathrin and caveolin-1 expression in primary pigmented rabbit conjunctival epithelial cells role in PLGA nanoparticle endocytosis. Mol Vis 9 559-568 (2003)... 

Cremaschi, D., et al. 1996. Endocytosis inhibitors abolish the active transport of polypeptides in the mucosa of the nasal upper concha of the rabbit. Biochim Biophys Acta Biomemb 1280 27. 

H. Tomoda, Y. Kishimoto, and Y. C. Lee, Temperature effect on endocytosis and exocytosis by rabbit alveolar macrophages, J. Biol. Chem. 264 15445-15450 (1989). 

Connolly DT, Townsend RR, Kawaguchi K, Bell WR, Lee YC. Binding and endocytosis of cluster glycosides by rabbit hepato-cytes. Evidence for a short-circuit pathway that does not lead to degradation. J. Biol. Chem. 1982 257 939-945. 

OTA is thought to be transported into the proximal tubular epithelium via organic anion transporters. In primary rabbit proximal tubule cells cultured on microporus supports OTA was taken up from the basolateral compartment and secreted into the apical compartment. This process was sensitive to probenecid [198]. Mouse proximal tubular cells transfected with hOATs (1, 3 and 4) exhibited an enhanced uptake of OTA which was also inhibited by probenecid [199, 200]. However, it is also known that OTA has a high affinity for albumin and it has been demonstrated experimentally that human serum albumin dose depend-ently decreases OTA uptake via hOATl [201]. Whether albumin bound OTA can be transported via megalin mediated endocytosis has not been investigated. 

Ultrastructural changes of proximal tubular cells occur as early as 1 hour after cephaloridine administration to rabbits and are characterized by loss of brush border, less elongated mitochondria and disappearance of structures associated with endocytosis. Later ultrastructural changes include disorganization of lateral interdigitations of plasma cell membrane and mitochondrial swelling [28,29]. 

Hence, most of the studies describing direct effects of Cd on the function of transporters (reviewed in [277]) may have only in vitro or mechanistic relevance and are not likely to significantly contribute to in vivo toxicity of Cd in tissues. Indeed, few mammalian transporters are directly affected by submicromolar Cd concentrations Ca-ATPase of rat intestinal and renal basolateral plasma membrane is blocked with an IC50 of 1.6 nM [464] and apical Na-dependent glucose and amino transporters of isolated rabbit PT (S2-segment) by nanomolar concentrations of CdMT [221]. However, it cannot be excluded that the effects observed were due to CdMT-induced endocytosis of apical membranes containing Na-dependent... 

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