Rabbit thrombogenicity model

Handa, H., Major, T.C., Brisbois, E.J., Amoako, K.A., Meyerhoff, M.E., Bartlett, R.H. Hemocompatibility comparison of biomedical grade polymers using rabbit thrombogenic-ity model for prepeuing nonthrombogenic nitric oxide releasing surfaces. J. Mater. Chem. B Mater. Biol. Med. 2(8), 1059-1067 (2014)... 

TFPI, when administered to rabbits, has been shown to have an antithrombotic effect when thromboplastin was used as a thrombogenic challenge (I 10). TFPI was also shown to be an effective inhibitor when thrombosis was induced in rabbit jugular veins by endothelial destruction and restricted blood flow. The antithrombotic and antiprotease actions of TFPI have been tested in several other animal models. Warn-Cramer et al. investigated the effect of immunodepletion of TFPI in factor Vila and Xa induced coagulation in rabbits (III). These rabbits were observed to be sensitized to the procoagulant effects of factor Vila, but not factor Xa in the absence of factor Vila. Two studies have indicated that TFPI administration reduces the lethal effects of . coli administration in a septic shock model in baboons (I 12). These studies also indicated that TFPI may have an anti-inflammatory effect, as an attenuation of the IL-6 response was also observed. Administration of TFPI has been observed to prevent... 

Major, T.C., Handa, H., Annich, G.M., Bartlett, R.H., 2014b. Development and hemocompatibility testing of nitric oxide releasing polymers using a rabbit model of thrombogenicity. Journal of Biomaterials Applications 29,479-501. 

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