Quisqualis Quisqualic acid

Aziridine 269 (Scheme 3.98), on treatment with pyrazole (270) and subsequent TFA deprotection, gave P-pyrazolylalanine 271, first isolated from Citrullus vulgaris (a water melon) and isosteric with histidine [148]. Treatment of 269 with 1,2,4-ox-adiazolidine-3,5-dione 272 gave (S)-quisqualic acid (273), an active ingredient of the ancient Chinese drug Shihchuntze, an anthelmintic made from the seeds of Quisqualis indica [148]. 

Quisqualis grandiflora Miq. Q. indica L. Q. longifolia Presl. Q. loureiri G. Don. Q. pubescens Bunn. Q. sinensis Lindl. Shi Jiun Zi (Rangoon creeper) (fruit) Quisqualic acid, trigonelline 33,235 Treat internal parasites. 

Quisqualic acid (= Spa.- Quisqualis chinensis, (X indica iGlu-R agonist (pulmonate... 

Quisqualic acid (= (S)-a- Quisqualis chinensis, (A indica mClu-R (Class 1) agonist - Class... 

The anthelmintically active plant Quisqualis indica contains its active principle quisqualic acid (13) (found as its potassium salt) located in the )[Pg.324]

The seeds of Quisqualis indica are commonly used in China to treat ascariasis. The active component is quisqualic acid (207). In clinical trials, potassium quisqualate (125 mg) showed anthelmintic activity equi-... 

In this chapter, quisqualic acid, isolated from the fruits of Quisqualis indica, is described. Quisqualic acid is biosynthesized from 2,3-diaminopropionic acid. On the other hand, it can be said that quisqualic acid is biosynthesized from 2-amino-3-ureidopropionic acid, which is a derivative of 2,3-diaminopropionic acid. The former amino acid (2-amino-3-ureidopropionic acid) was isolated from the seeds of the silk tree Albizzia julibrissin) (Fabaceae) and was named albizziin. 

As an active component with anthelmintic activity, quisqualic acid was isolated and its chemical structure determined [IJ.The alkaloid was previously isolated from the fruit of Quisqualis chinensis and Q. indica and its anthelmintic activity reported [2,3]. 

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