Quiocho, Florante

David K. Wilson and Florante A. Quiocho Baylor College of Medicine, Houston, Texas... 

Like many other useful discoveries, enzyme immobilization by cross-linking was actually an unintended by-product of another research project. In 1964, Florante Quiocho and Frederic Richards at Yale university cross-linked crystals of carboxy-peptidase-A with glutaraldehyde (pentane-1,5-dial), hoping to get stable crystals for X-ray diffraction studies. They noted that these cross-linked enzyme crystals (now... 

Dr. Florante A. Quiocho Howard Hughes Medical Institute Baylor College of Medicine One Baylor Plaza Houston, TX 77030, U.S.A. 

Concanavalin A, was solved here to 4 A resolution, by Florante Quiocho. The refinements are detailed in the Ph.D. thesis of Brian Edwards, who did most of the calculations on Quiocho s data. We entered a collaboration with Gerald Edelman at Rockefeller University, where the sequence was being done and where George Reeke, Jr. was just then setting up a new laboratory for protein... 

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