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8-Quinolyl phosphate hydrolysis

The base hydrolysis under harsh conditions very often brings about undesired cleavage of phosphates. In contrast, removal of an o- orp-chlorophenyl protecting group by lV ,iV, iV, /V -tetramethylguanidinium ryn-p-nitrobenzaldoxymate (NBO) (108 equation 65) or syn-pyridin-2-aldoxymate (PAO) (109) is achievable at room temperature and no side reaction occurs. The 8-quinolyl phosphate (110 equation 66) is also hydrolyzed under mild conditions with the assistance of a stoichiometric amount of ZnCb or CuCb salt. ... [Pg.624]

Hydrolysis of 8-quinolyl phosphate (98) (8QP) in the presence of trivalent lanthanides (Ln-La, Sm, Eu, Tb, and Er) proceeded through formation of an [Ln 8QP] complex that decomposed into the product (99) (Scheme 21)." The lanthanides favored a single-step DnAn mechanism with a dissociative transition state, a limited nucleophilic assistance, a low hydroxide ion dependence and a small kinetic effect of Ln radii. [Pg.231]

See other pages where 8-Quinolyl phosphate hydrolysis is mentioned: [Pg.445]    [Pg.445]    [Pg.6590]    [Pg.624]    [Pg.25]   
See also in sourсe #XX -- [ Pg.6 , Pg.624 ]

See also in sourсe #XX -- [ Pg.624 ]

See also in sourсe #XX -- [ Pg.6 , Pg.624 ]

See also in sourсe #XX -- [ Pg.624 ]



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