Quinolone-DNA-enzyme complex

Both ciprofloxacin (7) and ofloxacin (8) are, needless to say, fluoroquinolone antibiotics. Their targets are well known they inhibit bacterial DNA gyrase (topoisomerase II) and topoisomerase IV. These two enzymes are essential for the uncoiling of DNA. It is believed that quinolones bind to complexes formed between DNA and one of the two germane enzymes to afford a quinolone-DNA-enzyme complex. The quinolone complex... 

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