Quinolinecarboxylic add

CN m-5-Amino-l-cyclopropyl-7-(3,5 dimethyl-l-piperaz.myl)-6,8-dilluoro-l,4-dihydro-4-oxo-3-quinolinecarboxylic add... 

Oxolinic Acid, 5-Efhyl-5,8-di/iyd -8-oxo-i,J-dioxolo[4,5-g]quirtoline-7-carboxcylic acid I-ethyl-1,4-dihydro -6,7 -methylenedioxy -4 -oxo -3 -quinolinecarboxylic add 1 -ethyl -6,7 -methylenedioxy -4-quinolone -3 -carboxylic add W 4565 Emyrenil Nidantin Ossian Oxoboi Pietil Pro-doxol Urinox Uritratc Uro-Alvari Urotrute Uroxin Von Boch Uroxol Utibid. CuH.-NO, mol wt 261.24. C 59.77%, H 4.25%, N 5.36%, O 30.62%. Quioolone antibacterial. Prepn Kaminsky, Meltzer, U.S. pat. 3,287,458... 

Fluorine is used for the fluorination of sites x to sulfoxides with simultaneous oxidation of the sulfoxide moiety to a sulfone. The electrophilic fluorine attacks the electron lone pairs of the sulfur atom with a consequent loss of hydrogen fluoride forming an S-fluorosulfoxy alkene. A second molecule of fluorine adds across the newly formed double bond resulting, after hydrolysis, in an a-fluoro sulfone 12.88 This reaction is used for the construction of a fluorocy-clopropane derivative 13 which is essential in the synthesis of one of the most promising members of the quinolinecarboxylic acid antibiotics.89... 

Maslennikov E, Strunin B, Kalashnik V, Gusejnov F, Khaev E, Kovalev V (2003) Cyclocondensation method for preparing ethyl-6-fluoro-7-chloro-l,4-dihydro-4-oxo-3-quinolinecarboxylate from diethyl-2-(3-chloro-4-fluoroanilinometylenecarboxylate add-Et ester. RU Patent 2206564,20 June 2003... 

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