Quinazolines structure-activity relationship

Lemus, R. H. Skibo, E. B. Design of pyritnido[4.5-s quinazoline-based anthraquinone mimics, structure-activity relationship for quinone methide formation and the influence of internal hydrogen bonds on quinone methide fate. J. Org. Chem. 1992, 57, 5649-5660. 

Rastelli, G., Fanelli, F., Menziani, M.C., Cocchi, M. and De Benedetti, P.G. (1991) Conformational analysis, molecular modeling and quantitative structure-activity relationships studies of 2,4-diamino-6,7-dimethoxy-2-substituted quinazoline al-adrenergic antagonists. Journal of Molecular Structure (Theochem), 251, 307—318. 

Blyn, L. B., Wyatt, J. R., Cook, P. D., Ecker, D. J. Structure—activity relationships of novel 2-substituted quinazoline antibacterial agents. J Med Chem 1999, 42, 4705-4713. 

Ghose, A.K. and Crippen, G.M. (1982). Quantitative Structure-Activity Relationship by Distance Geometry Quinazolines as Dihydrofolate Reductase Inhibitors. J.Med.Chem., 25, 892-899. 

Jantschi, L. and Bolboaca, S. (2006) Molecular descriptors family on structure-activity relationships. 5. Antimalarial activity of 2,4-diamino-6-quinazoline sulfonamide derivates. Leonardo Journal of Sciences, 8, 77-88. 

Varano F, Catarzi D, Colotta V et al (2008) Novel AMPA and kainate receptor antagonists containing the pyrazolo[l, 5-c]quinazoline ring system Synthesis and structure-activity relationships. Bioorg Med Chem 16 2617-2626... 

Storelli, S., Verdijk, P., Verzijl, D., Timmerman, H van de Stolpe, A.C., Tensen, C.P., Smit, M.J., De Esch, I.J.P. et al. (2005) Synthesis and structure-activity relationship of 3-phenyl-3H-quinazolin-4-one derivatives as CXCR3 chemokine receptor antagonists. Bioorganic Medicinal Chemistry Letters. 15, 2910-2913. 

The preparation of a sequence of quinazolines inserted at C4 by aminothiazole ring is reported [111]. Their in vitro structure-activity relationships against Aurora A and B serine-threonine kinases are examined. The results reveal that quinazolines with a substituted aminothiazole... 

The present review covers the literature to the end of 1967 and all original sources have been consulted. Syntheses of each of the four ring systems are summarized separately, but physical, chemical, and biological properties are considered generally. Many pjTidopyri-midines were initially synthesized for a study of biological activity or physical properties because of the close structural relationship of these systems to the quinazolines (5) and pteridines (6). Recent reviews have discussed these related compounds. 

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