Kainate receptor antagonists

Sutton, J.L., Maccecchini, M.L., Kajander, K.C. The kainate receptor antagonist 2S,4R-4-methylglutamate attenuates mechanical allodynia and thermal hyperalgesia in a rat model of nerve injury, Neuroscience 1999, 91, 283-292. 

Ta, L.E., Dionne, R.A., Fricton, J.R., Hodges, J., Kajander, K C. SYM-2081 a kainate receptor antagonist reduces allodynia and hyperalgesia in a freeze injury model of neuropathic pain, Brain Res. 2000, 858, 106-120. 

Fig. 2.5 Structures of kainate and AMPA receptor antagonists. LY382884 (a) and LY382884 diethyl ester (b) are kainate receptor antagonists CP-465022 (c), GYKI 52466 (d) CFM-2 (e) and GYKI 53655 (R= CONHMe) (f) are AMPA receptor antagonists...

Shimizu-Sasamata M., Kawasaki-Yatsugi S., Okada M., Sakamoto S., Yatsugi S., Togami J., Hatanaka K., Ohmori J., Koshiya K., Usuda S., and Murase K. (1996). YM90K pharmacological characterization as a selective and potent alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor antagonist. J. Pharmacol. Exp. Ther. 276 84-92. 

Varano F, Catarzi D, Colotta V et al (2008) Novel AMPA and kainate receptor antagonists containing the pyrazolo[l, 5-c]quinazoline ring system Synthesis and structure-activity relationships. Bioorg Med Chem 16 2617-2626... 

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