Quercetin 2,5-dioxygenase oxidative cleavage

Copper dioxygenase Quercetinase Fungal Quercetin oxidative cleavage... 

The bacterial degradation of quinoline heterocycles proceeds via oxidation to 3-hydroxy-4-oxoquinolines, which are substrates for a novel family of dioxygenases. The reaction is similar to the copper-dependent quercetin dioxygenase (see Section 8.16.4.2), involving oxidative cleavage of two C—C bonds, and liberation of carbon monoxide however, remarkably, these enzymes have no cofactor requirement. Two dioxygenases QDO... 

The copper-containing fungal dioxygenase, quercetinase, catalyzes the oxidative cleavage of quercetin (15), a heterocyclic... 

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