Quantitative Dose-Response Assessment Currently Used Approaches

3 QUANTITATIVE DOSE-RESPONSE ASSESSMENT CURRENTLY USED APPROACHES 

Previously the LMS model (Section 6.2.1.2) was the most widely adopted approach for low-dose extrapolations for data from studies in experimental animals. More recently, an MOE approach has 

Toxicological Risk Assessments of Chemicals A Practical Guide 

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The quantitative dose-response assessment involves two different challenges, namely to determine the relationship between doses and the frequency of cases of cancer (i.e., potency evaluation), and to determine what statistical risk is tolerable or acceptable. This section gives a very short overview of some general aspects related to the quantitative dose-response assessment. The currently used approach by the WHO, the US-EPA, and the EU, as well as new approaches for the risk assessment of compounds that are both genotoxic and carcinogenic, are presented in Sections 6.3 and 6.4, respectively. 

Currently, human risk assessment utilising the target dose approach must be based on quantitative dose-response data generated in one or more presumed-sensitive biological models. The risk estimates developed using this approach must be carefully checked against the results of current and future human epidemiological studies. 

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