Quality attributes equilibrium

The search for relationships among the dynamic and equilibrium properties of related series of compounds has been a paradigm of chemists for many years. The discovery of such unifying principles and predictive relationships has practical benefits. Numerous relationships exist among the structural characteristics, physicochemical properties, and/or biological qualities of classes of related compounds. Perhaps the best-known attribute relationships are the correlations between reaction rate constants and equilibrium constants for related reactions commonly known as linear tree-energy relationships (LFERs). The LFER concept led to the broader concepts of QSARs, which seek to predict the environmental fate of related compounds based on correlations between their bioactivity or physicochemical properties and structural features. For example, therapeutic response, environmental fate, and toxicity of organic compounds have been correlated with... 

The relaxation process observed by NRET, SANS, and sedimentation velocity (systems close to equilibrium) has been attributed to the copolymer exchange. The results showed that the copolymer exchange rate is extremely sensitive to the solvent quality and to the temperature. This is illustrated in Figure 4.11 for solutions of poly(st3rrene)-poly(hydro-genated isoprene) in dioxane/heptane mixtures in which micelles form with a poly(st3rrene) core. A... 

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