Qinghaosu antimalarial action

Wang, D.-Y. and Wu, Y.-L. 2000. A possible antimalarial action mode of qinghaosu (artemisinin) series compounds. Alkylation of reduced glutathione by C-centered primary radicals produced from antimalarial compound qinghaosu and 12-(2,4-dimethoxyphenyl)-12-deoxoquighaosu. Chem. Common., 2193-2194... 

Early Biologically Morphologic Observation of the Antimalarial Action of Qinghaosu... 

Wang, D.-Y Wu, Y.-L. Wu, Y. K. Liang, J. Li, Y. Rurtherevidence fortheparticipation of primary carbon-centered free-radicals in the antimalarial action of the qinghaosu (artemisinin) series of compounds. J. Chem. Soc. Perkin Trans. 1, 2001, 605-609. 

Butler, A. R. Gilbert, B. C. Hulme, P Irvine, L. R. Renton, L. Whitwood, A. C. EPR evidence for the involvement of free radicals in the iron-catalysed decomposition of qinghaosu(artemisinin) and some derivatives Antimalarial action of some polycyclic endoperoxides. Free Rad. Res., 1998, 28 471 76. 

Artemisinin ( qinghaosu ) (18), a sesquiterpene lactone antimalarial compound with an endoperoxide group, discovered in the Peoples Republic of China as a constituent of Artemisia annua L., has created great interest in the biomedical community, owing to its unique mechanism of action on the heme complex. Artemisinin serves as an option for the treatment of chloroquine (4l)-resistant malaria and is used in some Asian countries as an antimalarial. However, the use of artemisinin as a single agent anti-malarial is a potential risk since the malaria parasite may become resistant to this compound class. 

China Cooperative Research Group on Qinghaosu and its Derivatives as Antimalarials. Antimalarial efficacy and mode of action of qinghaosu and its derivatives in experimental models. J. Trad. Chin. Med., 1982, 2(1) 17-24. 

Cumming, J. N. Posner, G. H. Antimalarial activity of artemisinin (qinghaosu) and related trioxanes Mechanism(s) of action. Adv. Pharmacol. San Diego), 1997, 37 253-297. 

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