Pyruvate reductases acid dehydrogenases lactate

Dehydrogenases often act primarily to reduce a carbonyl compound rather than to dehydrogenate an alcohol. These enzymes may still be called dehydrogenases. For example, in the lactic acid fermentation lactate is formed by reduction of pyruvate but we still call the enzyme lactate dehydrogenase. In our bodies this enzyme functions in both directions. However, some enzymes that act mainly in the direction of reduction are called reductases. An example is aldose reductase, a member of a family of aldo-keto reductases71 73 which have (a / P)8-barrel structures.74 76... 

Lactate dehydrogenase (LD, oxido-reductase, EC 1.1.1.27) Pyruvate and other ketoacids + NADH. Also lactate and other a-hydroxy acids + NAD Moderately specific... 

Following an abrupt transition of P. pentosaceum from anaerobic to aerobic metabolism (10 pM O2), the growth rate increases at first, but the formation of acetate from lactate and glucose is slowed down, propionate formation is completely repressed and pyruvate is accumulated in the medium (van Gent-Ruijters et al, 1976 Schwartz et al, 1976). A decrease in the activities of the citric acid cycle enzymes malate dehydrogenase, fumarase and NADH oxidase, lactate oxidase, NADH-dependent fiimarate reductase, lactate-dependent nitrate reductase is observed upon the transition from anaerobic to aerobic (10 pM O2) metabolism (van Gent-Ruijters, 1975). 

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