Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Pyruvate formate-lyase inactivation

E. Inactivation of Pyruvate Formate-Lyase by Acetyl Phosphinate. 380... [Pg.318]

Compounds Tested as Inactivators of Pyruvate Formate-Lyase... [Pg.372]

The inhibition of pyruvate formate-lyase by hypophosphite was first observed by Novelli in work on the CoA-independent carboxylate exchange reaction between pyruvate and formate (186). In a more detailed study by Knappe et al., time-dependent inactivation is observed to occur with concomitant loss of the enzyme free radical EPR signal (180). The inactivation kinetics are first order and the rate of inactivation is accelerated when the enzyme is in the acetylated form. Furthermore, inactivation by [ HJhypophosphite leads to the stoichiometric release of tritium to H2O, and treatment of PFL with [ P]hypophosphite produces an alkali-labile radiolabel that is covalently bound to the inactive enzyme (180). [Pg.372]

See other pages where Pyruvate formate-lyase inactivation is mentioned: [Pg.1350]    [Pg.318]    [Pg.372]    [Pg.372]    [Pg.382]    [Pg.163]    [Pg.449]    [Pg.157]    [Pg.189]    [Pg.477]    [Pg.1146]    [Pg.147]    [Pg.161]    [Pg.715]   
See also in sourсe #XX -- [ Pg.372 ]



SEARCH



Lyase

Lyases

Pyruvate formate lyase

Pyruvate formation

Pyruvate lyase

© 2024 chempedia.info