Pyrido pyridazines

The final chapter by Istvan Hermecz (Chinoin, Ltd., Budapest, Hungary) deals with bicyclic systems containing one ring junction nitrogen and one heteroatom and their benzologs, i.e. pyrido-oxazines, pyrido-thiazines, pyrido-pyridazines, pyrido-pyrazines, pyrido-pyrimidines and their analogs. Much of this material has not been reviewed for forty years, during which time immense advances have occurred. 

All six isomeric pyridopyridazine systems are now known, comprising pyrido[2,3-c]pyridazine (282), pyrido[2,3-d]pyridazine (283), pyrido[3,2-c]pyridazine (284), pyrido[3,4-c]pyridazine (285), pyrido[3,4-d]pyridazine (286) and pyrido[4,3-c]pyridazine... 

The NMR spectra of the parent compounds of the pyrido-[2,3-d]- and -[3,4- f]-pyridazine systems have been studied, together with those of some closely related derivatives parent compound, 282). In the pyrido[4,3-c]pyridazine series, only the spectrum of the dihydro compound (302) has been recorded <79X2027). 

The barriers to rotation in a series of (V,(V-dimethylformamidine derivatives of pyrido-[2,3-d]- and -[3,4-d]-pyridazines have been measured by an NMR method <78JHC1105), and NMR studies have also been used in a study of tautomerism in the latter system <75BSF702). 

The NMR spectra of pyrido[2,3-d]pyridazine Af-oxides reduced derivatives and quaternary salts have also been studied and alkaline deuterium exchange reactions investigated <77BSF919). 

The UV spectra of pyrido[2,3-d]pyridazine-l,4-diones have been recorded (68MI21501), whilst several of the latter were also used in chemiluminescence studies. Quinolinic and cinchomeronic hydrazides showed no chemiluminescence (60NKK173, 37JPR(148)135), but it was observed in the 8-hydroxy derivative (305) (72YZ703). 

Amongst miscellaneous UV spectra recorded are those of alkylthio adducts of pyrido[3,2-c]pyridazine (78KGS1272), various pyrido[3,4-d]pyridazines (57AC(R)728) and several vinyl-pyridine-azodicarboxylic ester adducts (79T2027, 79KGS639). 

Structural problems in the pyrido[3,4-c]pyridazine series (76CPB1870) and in the fused pyridazino[4,5-6]quinoline series (80CPB3457) have also invoked mass spectral determinations. 

There seems to have been no systematic study of tautomerism in the pyridopyridazines, but isolated observations in the pyrido[3,4-d]pyridazinedione (75BSF702, 69CPB2266) and pyrido[2,3-d]pyridazinedione (74JHC351) series have involved methylation studies. The pyrido[2,3-d]pyridazine-5,8-diones are believed to be enolized at the 8-position, from metal complexation results (67MI21500). 

True electrophilic substitution is very difficult in pyridopyridazines. For example, the [3,4-d] parent (286) is inert to hot 65% oleum (68AJC1291), and although formation of a 3-bromo derivative (308) was reported in the [2,3-d] series, it seems to have arisen by an addition-elimination reaction via the dibromide (309) (69AJC1745). Attempted chlorination led to ring opening. A similar effect was observed in the [3,4-d] system, where an 8-bromo derivative was obtained (77BSF665), and in iV-oxides of the pyrido[2,3-c]pyridazine and fused pyridazino[3,4-c]isoquinoline series (72JHC351). The formation of (311) from (310)... 

Protonation of pyrido[2,3-d]pyridazine (pK 2.01) is believed to occur at position 1 as predicted by MO calculations (68AJC1291), although alkylation results (see below) cast doubt on this. Covalent hydration has not been observed in this series, nor in the slightly weaker [3,4-d] base (pX a 1.76), which probably protonates at N-6, though this is not certain. 

The 6- and 7-quaternary salts of pyrido[2,3-d]pyridazine are reduced by borohydride with subsequent air oxidation to 5,6- and 7,8-dihydro oxo derivatives respectively (77BSF919), whilst the [3,4-d] analogues give the corresponding 1,2- and 3,4-dihydro oxo compounds 72CR(C)(275)1383). ... 

Acetyl (79GEP2808070,71FES1074) and Other groups on the pyridine ring have been oxidized to the corresponding carboxylic acids in the pyrido-[2,3-c]- and -[3,4-d]-pyridazine fields. Acid groups in pyridopyridazines behave normally on esterification (66CPB1010). 

Selective substitutions have been most studied in the pyrido[3,4-tf]pyridazine field. The 1,4-dichloro derivative (334) was more reactive than 1,4-dichlorophthalazine, and was expected from MO calculations to show a more reactive 4-chlorine group. In practice, however, almost equal amounts of monosubstitution products were observed on hydrolysis, although slight differences in the use of alkaline and acid conditions, or on hydrazination, have been reported (69CPB2266). Reaction of this 1,4-dichloro compound, or substituted... 

In forcing conditions with excess of reagents the 5,8-bis derivative was obtained in the above cases, with hydrazine and with sulfur nucleophiles. Other authors have also observed selective reactions in the pyrido[2,3-[Pg.242]

An important early method simulated the well-known Widman-Stoermer cinnoline synthesis. 3-Aminopyridine-2- or -4-alkenes such as (348) gave pyrido-[3,2-c]- or -[3,4-c]-pyridazines on diazotization and alkaline cyclization (66JCS(C)2053>. 

Few reactions of this type are recorded. The azidopyridazinone ester (349) on reduction with triethyl phosphite, hydrazine or borohydride furnished the pyrido[2,3-c]pyridazin-7-one (350) (79JHC1559), whilst an A-aminopyrido[2,3-c]pyridazine (352) resulted from the... 

The only example of a simple pyridopyridazine synthesis of this kind from a pyridine intermediate involves a variant of a well known cinnoline synthesis in which the Japp-Klingemann intermediate (363) gives the pyrido[3,4-c]pyridazine (364) with PPA (69JHC977). 

The only example from a pyridazine intermediate is of the Dieckmann-type used so widely in the pyridopyrimidine field (Section 2.15.5.4.2). The 3-carboxyalkylamino-4-ester (365) is cyclized by strong base to give the pyrido[2,3-c]pyridazine-6-carboxylate (366) (77JAP(K)7733695). 

The vast majority of syntheses of pyrido[2,3-t/]- and pyrido[3,4-t/]-pyridazines fall into this category, resulting from the cyclization of various o-substituted pyridine derivatives (2,3- or 3,4-, respectively) with hydrazine or its congeners. 

The other main source of various pyridopyridazines from pyridines are the [4 + 2] cycloaddition reactions, already mentioned (Section 2.15.8.3), between vinylpyridines and azodicarboxylic esters (79T2027, 79KGS639) or triazolidinediones e.g. 78KGS651). 2-Vinyl-pyridines gave reduced pyrido[3,2-c]pyridazines (370), 4-vinylpyridines gave [3,4-c] analogues, whilst 2-methyl-5-vinylpyridine furnishes a mixture of the [2,3-c] and [4,3-c] compounds. Yields are low, however, and these remain curiosities for practical synthetic purposes. 

Reduced pyrido[4,3-c]pyridazines are obtained from piperidine derivatives such as (371) with hydra2dne e.g. 79AF1835), whilst another related synthesis coupled the enamine (372) with phenacyl bromide semicarbazone to give (373) (74JAP(K)7488897). 

The only recorded synthesis of this type from a pyridazine involves the [4 + 2] cycloaddition of the lactim ether (374) with l,2,4,5-tetrazine-3,6-dicarboxylic ester, which proceeds with loss of nitrogen and methanol from the intermediate adduct to give the pyrido[2,3-t/]pyridazine (375) (77AP936). 

Finally, the activated 3-aminopyridazine AT-oxide (381), mimicking 6-aminouracil, cyclizes with /3-ketoesters to give the pyrido[2,3-c]pyridazin-7-one AC-oxide (382). A reduced fused... 

The nucleophilic substitution reactions in pyrido-[2,3-f>]- and -[3,4-f ]-pyridazines in general follow the usual pattern of polyaza heterocycles. Oxo groups in the 2-, 3- and 6-positions of [2,3-f ]-ones, and in the 2- and 3-positions of [3,4-f ]-ones have been... 

No natural products or their analogues are included among the pyridopyridazines, but several interesting biologically active compounds have emerged. Some l-chloro-4-hydrazino- and 4-chloro-l-hydrazino-pyrido[2,3-d]pyridazines (460) are very active hypotensives, whilst related dialkoxy compounds have anticonvulsant activity (65CPB586). 

Similarly, hypotensive activity is found in other analogues of hydralazine, including the very active endralazine (461) (79AF1835, 79AF1843), a pyrido[4,3-c]pyridazine. 

Pyrido[2,3-c]pyridazine, N-amino-synthesis, 3, 243-244 Pyrido[2,3-c]pyridazine, 7-methyl- H NMR, 3, 234... 

Pyrido[2,3-d]pyridazine, 1 -chloro-4-hydrazino-biological activity, 3, 261 Pyrido[2,3-(i]pyridazine, 4-chloro-l-hydrazino-biological activity, 3, 261 Pyrido[2,3-(i]pyridazine, 5,8-dichloro-nucleophilic substitution, 3, 242 Pyrido[2,3-(i]pyridazine, polyhalo- H NMR, 3, 234... 

Pyrido[3,4-i]pyridazine, 2,3-dimethyl-bromination, 3, 252 Pyrido[3,4-c]pyridazine, 4-methyI-reactions, 3, 240 Pyrido[3,4-(i]pyridazine, acetyl-oxidation, 3, 240... 

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