Pyridine, antifungal activity

Monosubstituted pyrrolo[2,3- ]pyridine derivatives substituted at positions 2 or 6 of the ring system, 26, exhibit antifungal activity against Pyricularia oryzae, a fungus that causes rice blast <1997JFA2345>. 

The oxazolo[5,4-f]pyridine 213 is just one example of a series of compounds which have antifungal activity <2003EUP1275653>. 

Table 12 Antibacterial and antifungal activities of quinolinone-pyridines...

These include association, complexes, and environmental factors for acetates, benzoates471, carboxylatcs substituted pyridines, dithiophosphorus and carbon ligands, and a range of nitrogen derivatives. The antifungal activity and spectral characteristics of tin-sulphur compounds are measured and equUibria of organolead halide adducts measured and compared. ... 

Chate et al. [94] described an efficient and eco-friendly synthesis of a novel series of chromones under ultrasonic irradiation of l-(2-hydroxyphenyl)-3-(pyridine-3-yl)propane-l,3-dione (108), providing the corresponding 2-(pyri-dine-3-yl)-4H-chromen-4-one derivatives (109) with good yields in shorter reaction times (Scheme 26). These derivatives were evaluated for their antibacterial and antifungal activities and were foxmd to be comparable to the reference standard drugs tested. 

El-Sayed et al. [26] reported synthesis and antimicrobial evaluation of several quinoline and pyrimidoquinoline derivatives. The pyridine containing compounds were exerted strong antibacterial and antifungal activities, especially when a methoxyl group was located in the 7-position of quinoline nucleus. 

Nirmal et al. have synthesized biquinoline adducts (18) in high yields by the cycli-zation of [(2-chloro-3-quinolyl)methylene]methane-l,l-dicart>onitriles (16), which was provided from reaction between aldehyde (1) and malononitrile, with 3-aryl-amino-5,5-dimethyl-cyclohex-2-en-l-ones (17) under MWI catalysed by 4-(A7, N-dimethylamino)pyridine (DMAP Scheme 6.8). The synthesized compounds were screened for their antifungal and antibacterial activities [46]. 

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