Indeno pyrazoles

Shu-Jiang and co-workers [76] have developed a green approach for the synthesis of biologically important indeno[2,l-c]pyrazolo[5,4-/7]pyridines 36 via a MCR of a suitable aldehyde, 3-methyl-l-phenyl-l//-pyrazol-5-amine and 1,3-indane-dione in water under microwave irradiation without the aid of any catalyst. This protocol has the prominent advantages of being environmentally benign and having... 

A 1,3-dipolar cycloaddition of indanoneenamines and nitrilimines produces the indeno[2,l-c]pyrazole (52). The yields of such cyclization reactions are high (60-80%). Reactions of A/-alkylpyridine-3-ylides with picryl chloride involving cyclization give a mixture of pseudoazulenes 35 and 36. An additional preparation of pyrindine 26 is from 1,2- and... 

Indenoll,2-e]-l,4-diazepin-6-one, 838, 976 Indeno[2,l-[Pg.772]

In general, pyrolysis of monocyclic 1,2,3-triazines 1 leads to acetylenes, nitriles and nitrogen.46, 295 297 300 Heating simple 1,2,3-triazines in a sealed tube led to the isolation of pyridines, pyrimidines, pyrazoles, pyrroles, pyridazine, and indeno[3,2-/>]pyridine, depending on the substituents bound to the 1,2,3-triazine ring and the reaction conditions.46 A mechanism formulated for the formation of these products involves an azete as an intermediate. 

An efficient three-component domino strategy for the synthesis of multi-functionahzed tetracyclic indeno[l,2-h]indole derivatives has again been reported by Tu, li, and coworkers [62]. The domino reaction between enaminones 57 and 2,2-dihydroxyindene-l,3-dione 105 in acid anhydride generated the fused pyrazoles 106 (tetracyclic 6-5-S-6 skeleton), which involved a nucleophilic substitu-tion/cychzation/methyl migration/aromatization/esterification. On the other hand,... 

Dimethoxy-2-phenyl- [indeno-1. 2 -. 3.4-pyrazol]-carbonaanie.(6) 25 II213. 

Addition of 2-substituted-iV-phenylhydrazinecarbothioaniides 26a—d in dry pyridine to 3 gave, upon chromatographic separation of the residue, numerous zones. The 3-cyano-4-oxo-phenyl-indeno[l,2-c]pyrazole-l(4fi)-carbothioamides 89 (Scheme 27, 07JCR629) were isolated as one of the products. 

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