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Pyrazinecarboxamides

Therapeutic Function Antibacterial (tuberculostatic) Chemical Name Pyrazinecarboxamide Common Name —... [Pg.1330]

QiiHioiNOioSij I286S4-97-9) see Tacrolimus Ar-(l,l-dimethylethyl)pyrazinecarboxamide (C,H jNjO 121885-10-7) see Indinavir sulfate (l,l-dimethylethyl)[[(3P E,7E,22 )-9,10-secoergosta-5,7,10(19),22-tetraen-3-yl]oxy]dimethylsilane (CMHjgOSi 104846-63-1) see Calcipotriol iV-(l,l-dimethylethyl)-l,4,5,6-tetrahydropyrazine-carboxamide... [Pg.2365]

To synthesize pyrazinecarboxylic esters and pyrazinecarboxamides, chloropyrazines were subjected to Pd-catalyzed carbonylation reactions in either alcohols or dialkylamines [44, 45]. 2-Chloro-3,6-dimethylpyrazine (23) was smoothly carbonylated in methanol containing a catalytic amount of Pd(dba)2 and Ph3P to give 2-methoxycarbonyl-3,6-dimethylpyrazine (70). Somewhat lower yields were observed in the preparation of pyrazinecarboxylic diesters under the same conditions. [Pg.365]

Pyrazinecarboxamide [98-96-4] M 123.1, m 189-191" (sublimes slowly at 159"). Crystd from water or EtOH. [Pg.316]

Bis(benzylideneamino)-2-cyanoacrylamide (58) gave a separable mixture of 3-cyano-5,6-diphenyl-4,5-dihydro- (59a) and 3-cyano-5,6-diphenyl-l,6-dihydro-2-pyrazinecarboxamide (59b) (Me2SO, 80°C, 10 min 10 and 68%, respectively) ... [Pg.10]

I Iydroxyethyl-l,3-dimethyl-2,4(l//, 3//)-pteridincdionc gave 6-(2-hydrox-yethyl)-Af-methyl-3-methylamino-2-pyrazinecarboxamide (NaBH4 NaOH,... [Pg.66]

This process was undoubtedly developed for the manufacture of pyrazinamide (Zinamide, etc.),1696 a second-line drug for Mycobacterium tuberculosis infections, resistant to more effective and less toxic agents. Thus a mixture of 2-methyl-pyrazine (323), ammonia, oxygen, and steam is passed (at 400°C) over an alumina- or pumice-supported catalyst comprising one to three oxides of Ce, Cr, Mo, Mn, P, Sb, Ti, or (most importantly) V the main product (in up to 90% yield) is 2-pyrazinecarbonitrile (324), easily converted into 2-pyrazinecarboxamide... [Pg.128]

Oxo-3, 4-dihydro-2-pyrazinecarboxamide (13) gave 3-chloro-2-pyrazinecar-boxamide (14) (POCl3, pyridine, 40 — 80°C, 4 h 86%) 1119 also corresponding acid.275... [Pg.139]

Chloro-2-pyrazinecarboxamide (135, R = Cl) gave 5-methoxy-2-pyrazinecar-boxamide (135, R = OMe) (MeONa, MeOH, reflux, 2 h 94%).1681 Also other examples.1271... [Pg.164]

Chloro-2-pyrazinecarboxamide (136) gave 3-thioxo-3,4-dihydro-2-pyrazinecarboxamide (137) (NaHS, EtOH—Me2NCHO, 100°C, 5 h 85%) 503 the isomeric 6-thioxo-l,6-dihydro-2-pyrazinecarboxamide (84%) was made in a similar way.503... [Pg.164]

See other pages where Pyrazinecarboxamides is mentioned: [Pg.893]    [Pg.166]    [Pg.342]    [Pg.1366]    [Pg.1752]    [Pg.258]    [Pg.260]    [Pg.839]    [Pg.370]    [Pg.1162]    [Pg.366]    [Pg.276]    [Pg.277]    [Pg.279]    [Pg.300]    [Pg.321]    [Pg.194]    [Pg.166]    [Pg.838]    [Pg.746]    [Pg.134]    [Pg.2348]    [Pg.2349]    [Pg.2349]    [Pg.2349]    [Pg.2914]    [Pg.246]    [Pg.103]    [Pg.1752]    [Pg.1]    [Pg.1]    [Pg.1]    [Pg.11]    [Pg.64]    [Pg.65]    [Pg.81]    [Pg.133]    [Pg.157]   
See also in sourсe #XX -- [ Pg.321 ]

See also in sourсe #XX -- [ Pg.321 ]



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2-Pyrazinecarboxamide

2-Pyrazinecarboxamide

2-Pyrazinecarboxamide 4-oxide

2-Pyrazinecarboxamide dehydration

3- Benzamido-6-bromo-2-pyrazinecarboxamide

3- Chloro-5-cyano-2-pyrazinecarboxamide

3- Cyano-2-pyrazinecarboxamide

3-Amino-2 -pyrazinecarboxamide

3-Amino-6-methyl-5-phenyl-2-pyrazinecarboxamide

3-Amino-6-phenyl-2-pyrazinecarboxamide

3-Chloro-2-pyrazinecarboxamide

5-Methoxy-2-pyrazinecarboxamide

6- Chloro-2-pyrazinecarboxamide 4-oxide

Pyrazinecarbohydrazides Pyrazinecarboxamides

Pyrazinecarboxamides dehydration

Pyrazinecarboxamides from pyrazinecarbonyl halides

Pyrazinecarboxamides hydrolysis

Pyrazinecarboxamides reactions

Pyrazinecarboxamides reduction

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