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Pyrazinecarbaldehydes

T9637>. Reactions with ethyl formate or DMF give pyrazinecarbaldehydes 184 <1998X4899, 1998T9701>,... [Pg.315]

Note The reduction of C-acyl- to C-alkylpyrazines has been used occasionally 1022,1567 in addition, pyrazinecarbaldehydes react with methylene reagents to afford alkenylpyrazines, providing one or other reactant is preconverted into a Wittig reagent, as here illustrated. [Pg.103]

Methylthio-2-pyrazinecarbaldehyde (163, X = O) and the Witting reagent, (ethoxycarbonylmethylene)triphenylphosphorane, gave 2-(2-ethoxycar-bonylvinyl)-3-methylthiopyrazine (163, R = CH2C02Et) (neat reactants, N2, 135°C, 8 h 87%).1126... [Pg.103]

Hydroxymethyl-6-methyl-2,3-pyrazinedicarbonitrile (135) gave 5,6-dicyano-3-methyl-2-pyrazinecarbaldehyde (136) (activated Mn02, CH2C12, 20°C, 22 h 45%).1599... [Pg.212]

Amino-5-phenyl-2-pyrazinecarbaldehyde (19, R = H) gave 3-amino-5-phenyl-2-pyrazinecarboxylic acid (19, R = OH) (KMn04, HzO, 20°C, 1 h 28%).1385... [Pg.302]

Although most pyrazinecarbaldehydes are reasonably stable toward aerial oxidation, they are often stored or characterized only as their acetals, oximes, hydra-... [Pg.336]

Pyrazinecarbaldehydes can of course be recovered from their derivatives for example, the acetal, methyl 6-amino-5-cyano-3-diethoxymethyl- (249), gave methyl 6-amino-5-cyano-3-formyl-2-pyrazinecarboxylate (250) in 85% yield by selective hydrolysis in dilute hydrochloric acid at 20°C during 12 h 773 likewise, the extranu-clear acetal, 2-(3,3-diethoxypropyl)-3-ethoxycarbonylmethylpyrazine, gave 2-ethoxycarbonylmethyl-3-(2-formylethyl)pyrazine in 92% yield on hydrolysis in aqueous alcoholic hydrochloric acid at 35°C during 2 h.1249... [Pg.336]

Methoxypyrazine (251) gave 3-methoxy-2-pyrazinecarbaldehyde (252) (1,3,5-trioxane, 3% H2S04, FeS04, 30% H202) 13%), confirmed in structure by X-ray analysis of its 2,4-dinitrophenylhydrazone (253).1216... [Pg.337]

Reactions of pyrazinecarbaldehydes already discussed include reduction to hydroxyalkylpyrazines (Section 5.2.1) and oxidation to pyrazinecarboxylic acids (Section 8.1.1) no Cannizzaro disproportionations appear to have been reported recently. [Pg.338]

Dicyano-3-methyl-2-pyrazinecarbaldehyde (259) gave the Schiff base, 5-methyl-6-phenyliminomethyl-2,3-pyrazinedicarbonitrile (260) (PhNII2, A4 molecular sieves, AcOH, EtOH, 20°C, 4 h %).1599... [Pg.338]

Isopropyl-3,6-dimethoxy-2-methyl-2,5-dihydro-2-pyrazinecarbaldehyde (275) gave 2-(2,2-dibromovinyl)-5-isopropyl-3,6-dimethoxy-2-methyl-2,5-dihydropy-razine (276) (CBr4, PPh3, CH2C12, 0°C, A, 30 min then substrate j, 4 h ... [Pg.340]

Pyrazinecarbonitrile Oxides are unstable but they can be generated from pyrazinecarbaldehyde oximes with TV-chlorosuccinimide and then trapped immediately by appropriate dipolarophiles to afford cyclic adducts, as illustrated in the following examples ... [Pg.346]

Acetamido-2-pyrazinecarbaldehyde 3-Acetamido-2-pyrazinecarbohydr azide 3-Acetamido-2-pyrazinecarboxamide 6-Acetamido-2-pyrazinecarboxamide 6-Acetamido-2-pyrazinecarboxylic acid... [Pg.352]

Amino-6-cyclohexyl-2-pyrazinecarboxamide 3-Amino-5-cyclohexyl-2-pyrazinecarboxylic acid 3-Amino-6-cyclohexyl-2-pyrazinecarboxylic acid 3-Amino-/V-cyclopentyl-2-pyrazinecarboxamide 3-Amino-6-cyclopropyl-2-pyrazinecarbonitrile 3-Amino-6-cyclopropyl-2-pyrazinecarboxamide 3-Amino-6-cyclopropyl-2-pyrazinecarboxylic acid 3-Amino-5,6-dichloro-2-pyrazinecarbaldehyde 3-Amino-5,6-dichloro-2-pyrazinecarbonitrile 3-Amino-5,6-dichloro-2-pyrazinecarboxamide 3-Aniino-5,6-dichloro-2-pyrazinecarboxylic add 3-Amino-6-diethylaminomethyl-2-pyrazinecarbonitrile 3-Amino-5-diethylamino-2,6-pyrazinedicarbonitrile 5-Amino-3-dimethylamino-6-nitro-2-pyrazinecarbonitrile 3-Amino-5-dimethylamino-6-phenyl-2-pyrazinecarbohydrazide... [Pg.360]

Amino-3,6-dimethyl-2(177)-pyrazinone 3-Amino-5,6-diphenyl-2-pyrazinecarbaldehyde 3-Amino-5,6-diphenyl-2-pyrazinecarbohydrazide 3-Amino-5,6-diphenyl-2-pyrazinecarbonitrile... [Pg.361]

Amino-5-phenyl-2-pyrazinecarbaldehyde 3-Amino-5-phenyl-2-pyrazinecarbonitrile 3-Amino-6-phenyl-2-pyrazinecarbonitrile 3-Amino-6-phenyl-2-pyrazinecarbonitrile 4-oxide 3-Amino-A-phenyl-2-pyrazinecarboxamide 3-Amino-5-phenyl-2-pyrazinecarboxamide 3-Amino-6-phenyl-2-pyrazinecarboxamide 3-Amino-6-phenyl-2-pyrazinecarboxamide 4-oxide... [Pg.364]

Chloro-3,6-diisobutyl-2(17/)-pyrazinone 2-Chloro-3,6-diisopropyl-5-methylaminopyrazine 2-Chloro-3,6-diisopropylpyrazine 5-Chloro-3,6-diisopropyl-2-pyrazinecarbaldehyde 1-oxide 2-Chloro-3,6- diisopropylpyrazine 1 - oxide 2-Chloro-3,6-diisopropylpyrazine 4-oxide... [Pg.386]

See other pages where Pyrazinecarbaldehydes is mentioned: [Pg.277]    [Pg.1]    [Pg.1]    [Pg.1]    [Pg.53]    [Pg.65]    [Pg.117]    [Pg.117]    [Pg.181]    [Pg.315]    [Pg.315]    [Pg.336]    [Pg.336]    [Pg.337]    [Pg.337]    [Pg.338]    [Pg.339]    [Pg.339]    [Pg.339]    [Pg.340]    [Pg.340]    [Pg.374]    [Pg.388]    [Pg.388]    [Pg.394]    [Pg.398]    [Pg.400]    [Pg.400]    [Pg.402]    [Pg.403]    [Pg.403]    [Pg.407]    [Pg.407]   
See also in sourсe #XX -- [ Pg.336 ]

See also in sourсe #XX -- [ Pg.336 ]



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2-Pyrazinecarbaldehyde

2-Pyrazinecarbaldehyde

3 - Amino-5 -phenyl-2-pyrazinecarbaldehyde

3-Methoxy-2-pyrazinecarbaldehyde

3-Methylthio-2-pyrazinecarbaldehyde

Pyrazinecarbaldehydes oxidation

Pyrazinecarbaldehydes reduction

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