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Pyrazine 1,4-dioxide with acetic anhydride

Thin-layer chromatography indicates that prolonged reaction of pyrazine 1,4-dioxide with acetic anhydride gives the mono-iV-oxide, together with other unidentified products.406 Pyrazine mono-A-oxide is also formed on reaction of pyrazine-2-carboxylic acid 4-oxide with acetic anhydride.408... [Pg.197]

Other reactions with their counterparts in the pyridine series are also well known. Thus, 2,3-dimethylpyrazine 1,4-dioxide reacts with acetic anhydride to yield 2,3-bis(acetoxy-methyl)pyrazine (S3) in good yield (72KGS1275). Pyrazine 1-oxide also reacts directly with acetic anhydride to yield 2(ljH)-pyrazinone by way of the intermediate acetate (Scheme 22). The corresponding reaction in the quinoxaline series is not so well defined and at least three products result (Scheme 23) (67YZ942). [Pg.171]

Although Klein et al. (760) claimed that both pyrazine 1-oxide and 1,4-dioxide did not react with acetic anhydride, Asai (738) found that pyrazine 1-oxide when... [Pg.90]

Amino-3-cyano-5-methylpyrazine 1,4-dioxide (91) refluxed for several minutes with acetic anhydride formed 3-acetamido-2-cyano-5-hydroxy-6-methylpyrazine 1-oxide (92) (24%) (532) and 2-acetoxymethyl-5-methylpyrazine 1,4-dioxide refluxed with acetic anhydride afforded a mixture of2,5-di(acetoxymethyl)pyrazine 1-oxide, with some 2,5-diacetoxymethylpyrazine and a monoxide of 2-acetoxy-methyl-5-methylpyrazine (625). 2-Formylpyrazine hydrate 1,4-dioxide with aqueous sodium hydroxide or bicarbonate at < 37° in an unusual reaction gave 3-carboxy-pyrazine 1-oxide mixed with 5 [Pg.188]

Bauer and Hirsch (764) found that 2,5-dimethylpyrazine 1-oxide refiuxed for 2 hours with propane-1-thiol in acetic anhydride gave 2,5-dimethyl-3-propylthio-pyrazine (5), and 2,5-dimethylpyrazine 1,4-dioxide similarly treated gave 2,5-dimethyl-3,6-dipropylthiopyrazine, but attempted reactions with benzenesulfonyl chloride instead of acetic anhydride (as in the pyridine series) were unsuccessful. [Pg.198]


See other pages where Pyrazine 1,4-dioxide with acetic anhydride is mentioned: [Pg.91]    [Pg.22]   
See also in sourсe #XX -- [ Pg.91 ]




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2- pyrazine, with

Acetic anhydride with acetals

Pyrazine 1,4-dioxide

With acetic anhydride

With anhydrides

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