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PXR, Pregnane X receptor

A different pharmacophore [74], containing only one H-bond acceptor was suggested for the interaction of drugs with the transcriptional regulator PXR (pregnane X receptor) [75]. [Pg.475]

Figure 5.35 Mechanism of the receptor-mediated induction of CYP3A4 by a chemical. The inducer-receptor (PXR) complex enters the nucleus, binds with RXR, and the complex binds to the ER6 region of the CYP gene. This induces the production of CYP3A4 mRNA, which leads to the production of CYP3A4 protein and functional enzyme. Abbreviations RXR, retinoid X receptor-a PXR, pregnane X receptor ER6, everted repeat with a 6-kilobase spacer. Figure 5.35 Mechanism of the receptor-mediated induction of CYP3A4 by a chemical. The inducer-receptor (PXR) complex enters the nucleus, binds with RXR, and the complex binds to the ER6 region of the CYP gene. This induces the production of CYP3A4 mRNA, which leads to the production of CYP3A4 protein and functional enzyme. Abbreviations RXR, retinoid X receptor-a PXR, pregnane X receptor ER6, everted repeat with a 6-kilobase spacer.
Figure 9.10 Illustration depicting DNA elements found in CYP3A genes and the activation of the human pregnane X receptor (PXR) by ligand (RIF) and subsequent transcriptional activation of CYP3A4 gene by the PXR/RXR heterodimer. dNR-1-3, nuclear receptors 1, 2, and 3, respectively PXR, pregnane X receptor RXR, retinoid X receptor RIF, rifampicin SRC-1, steroid receptor co-activator XREM, xenobiotic responsive enhancer module. Figure 9.10 Illustration depicting DNA elements found in CYP3A genes and the activation of the human pregnane X receptor (PXR) by ligand (RIF) and subsequent transcriptional activation of CYP3A4 gene by the PXR/RXR heterodimer. dNR-1-3, nuclear receptors 1, 2, and 3, respectively PXR, pregnane X receptor RXR, retinoid X receptor RIF, rifampicin SRC-1, steroid receptor co-activator XREM, xenobiotic responsive enhancer module.
Abbreviations. PXR, pregnane X receptor CAR constitutive androstane receptor FXR, farnesoid X receptor. [Pg.177]

ER Estrogen Receptor, AR Androgen Receptor, GR Glucocorticoid Receptor, TR Thyroid Receptor, RAR Retinoic Acid Receptor, RXR Retinoie X Receptor, PR Progesterone Receptor, VDR Vitamin D Receptor, PPAR Peroxisome Proliferator-Activated Receptor, PXR Pregnane X Receptor, ROR Retinoic Acid-Related Orphan Receptor, NHF-4 Hepatocyte Nuclear Eactor 4, ERR Estrogen-Related Receptor... [Pg.2]

MAPK mitogen-activated protein kinase PXR pregnane X receptor... [Pg.577]

Beigneux, A. P., Moser, A. H., Shigenaga, J. K., Grunfeld, C., and Feingold, K. R. (2002) Reduction in cytochrome P-450 enzyme expression is associated with repression of CAR (constitutive androstane receptor) and PXR (pregnane X receptor) in mouse liver during the acute phase response. Biochem. Biophys. Res. Commun. 293, 145-149. [Pg.58]

See other pages where PXR, Pregnane X receptor is mentioned: [Pg.926]    [Pg.333]    [Pg.369]    [Pg.398]    [Pg.236]    [Pg.189]    [Pg.222]    [Pg.241]    [Pg.926]    [Pg.300]    [Pg.329]    [Pg.855]    [Pg.241]    [Pg.267]    [Pg.132]    [Pg.445]    [Pg.796]    [Pg.393]   
See also in sourсe #XX -- [ Pg.902 ]



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PXR

Pregnan

Pregnane

Pregnane X receptor

Receptors X receptor

Receptors pregnane X receptor

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