Puromycin-sensitive aminopeptidase

Proteosome component C2 Proteosome component Rpt2 Proteosome o6 subunit Proteosome o4 subunit Peptidyl prolylisomerase Prolj4 oligopeptidase Puromycin sensitive aminopeptidase Ubiquitin activating enzyme 1 Ubiquitin carboxy hydrolase... 

From the viewpoint of anticell invasion/adhesion activity, aminopeptidase-inhibitory activity has been investigated. The structural development studies of thalidomide (48) afforded specific dipeptidyl peptidase IV (DPP-IV) inhibitors [e.g., PPS-33 (55)] and specific puromycin-sensitive aminopeptidase (PSA) inhibitors [e.g., PIQ-22 (56a) PAQ-22 (56b)] (Fig. 8-14) [1-3,7,8,46-48]. DPP-IV appears to be involved in varions pathophysiological effects, inclnding tumor cell adhesion and the entry of hnman immnnodeficiency virus (HIV) into CD4+ T cells, and therefore DPP-IV inhibitors are expected to be... 

Aminopeptidases. These enzymes cleave the Tyr -Gly amide bond of the enkephalins releasing Tyr they include soluble aminopeptidase (EC 3.4.11.11 aminoacylpeptide hydrolase), aminopeptidase Mil (puromycin-sensitive aminopeptidase) and aminopeptidase M (EC 3.4.11.2 aminopeptidase N, puromycin-insensitive aminopeptidase). 

Tehier U, Nelson CH, Peterson LW, Provoda CJ, Hilfinger JM, Lee KD, McKenna CE, Amidona GL (2010) Puromycin-sensitive aminopeptidase an antiviral prodrug activating enzyme. Antiviral Res 85 482 89... 

A further complementary study (10AR482) suggested that the peptide prodmg Val—Ser (S)-cHPMPC 72b is initially activated through the cleavage ofL-valine by puromycin-sensitive aminopeptidase. Finally, uncatalyzed hydrolysis generates the active (S)-cHPMPC 56. Another study, led by... 

Menzies FM, Hourez R, Imaiisio S et al. (2010) Puromycin-sensitive aminopeptidase protects against aggregation-prone proteins via autophagy. Hum Mol Genet 19, 4573-4586. 

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