Adhesion invasion

Chen, J. and Thompson, L.U. 2003. Lignans and tamoxifen, alone or in combination, reduce human breast cancer cell adhesion, invasion and migration in vitro. Breast Cancer Res. Treat. 80, 163-170. 

Blumenthal RD, Hansen HJ, Goldenberg DM. Inhibition of adhesion, invasion, and metastasis by antibodies targeting CEACAM6 (NCA-90) and CEACAM5 (Carcinoembryonic Antigen). Cancer Res 2005 65 8809-17. 

On the contrary, they are extremely useful because in vitro studies minimize or eliminate variables that complicate interpretation, contribute to interexperimental variability, and cloud model development. Other chapters in this volume will focus on the proper use of and interpretation of in vitro assays of adhesion, invasion, etc. The focus of this chapter will be on the methodologies used to study metastasis in vivo. Parallel studies utilizing both in vivo and in vitro approaches are powerful strategies for dissecting the biochemical and molecular basis for cancer metastasis. 

Nicolson, G. L. (1988a) Organ specificity of tumor metastasis role of preferential adhesion, invasion and growth of malignant cells at specific secondary sites. Cancer Metastasis Rev. 7, 143-188. 

Nicolson, G. L., Belloni, P. N., Tressler, R. J., Dulski, K. M., Inoue, T. and Cavanaugh, P. G. (1989). Adhesive, invasive and growth properties of selected metastatic variants of a murine large-cell lymphoma. Invasion Metastasis 9, 102-116. 

Dunn, S. E., Ehrlich, M., et al. (1998). A dominant negative mutant of the insulin-like growth factor-I receptor inhibits the adhesion, invasion, and metastasis of breast cancer. 

Skorski T et al (1998) The SH3 domain contributes to BCR/ ABL-dependent leukemogenesis in vivo role in adhesion, invasion, and homing. Blood 91 406 418 Stambolic V et al (1998) Negative regulation of PKB/Akt-de-pendent cell survival by the tumor suppressor PTEN. Cell 95 29-39... 

Hwang ES, Lee HJ (2006) Inhibitory effects of lycoptaie tm the adhesion, invasion, and migration of SK-Hepl human hepatoma cells. Exp Biol Med (Maywood) 231 322-327... 

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