Purine bases nucleosides

Steenken, S. (1989). Purine bases, nucleosides and nucleotides aqueous solution redox chemistry and transformation reactions of their radical cations and e" and OH adducts. Chem. Rev. 89, 503-520. 

Names of Pyrimidine and Purine Bases, Nucleosides, and 5 -Nucleotidesa... 

Steenken S (1988) Electron transfer between radicals and organic molecules via addition/elimina-tion. An inner-sphere path. In Rice-Evans C, Dormandy T (eds) Free radicals chemistry, pathology and medicine. Richelieu Press, London, pp 53-71 Steenken S (1989) Purine bases, nucleosides and nucleotides Aqueous solution redox chemistry and transformation reactions of their radical cations e and OH adducts. Chem Rev 89 503-520 Steenken S (1992) Electron-transfer-induced acidity/basicity and reactivity changes of purine and pyrimidine bases. Consequences of redox processes for DNA base pairs. Free Radical Res Commun 16 349-379... 

Reagents A Convenient Route to sec- and tert- 6-Alkylpurines. Tetrahedron Lett. 1996, 37, 1285-1288. (c) Dvorakova, H. Dvorak, D. Holy, A. Synthesis of Acyclic Nucleotide Analogues Derived from 6-(sec- or tert-Alkyl) purines via Coupling of 6-Chloropurine Derivatives with Organocuprates. Collect. Czech. Chem. Commun. 1998, 63, 2065-2074. (d) Hocek, M. Holy, A. Perfluoroalkylation of 6-Iodopurines by Trimethyl(perfluoro-alkyl)silanes. Synthesis of 6-(Perfluoroalkyl)purine Bases, Nucleosides and Acyclic Nucleotide Analogues. Collect. Czech. Chem. Commun. 1999, 64, 229-241. 

Recently the interaction of arenediazonium ions with some purine bases, nucleosides and nucleotides was investigated Adenine, adenosine and 5 -adenylic... 

Purine bases, nucleosides and nucleotides, redox chemistry of in aqueous solution 89CRV503. 

Synthesis and biological activity of 2- and 6-C-substituted purine bases, nucleosides, and acyclic nucleotide analogs 00CLY978. 

Pmines are integral eomponents of RNA, DNA and eoenzyme that are synthesized in proliferaton of eaneer cells. Therefore, an agent that antagonizes the purine will certainly lead to formation of false DNA and these include analogues of natural purine bases, nucleosides and nucleotides. 

Examples of the resolution of a standard mixture of radioactive and nonradioactive purine bases, nucleosides and nucleotides is illustrated (Fig. 2). The profile of nonradioactive components documented by UV absorbance is presented by a continuous curve. The profile of radioactive components is documented by steplike curves. 

The pool of purine bases, nucleosides and nucleotides on body fluids and tissues has been assessed by reversed-phase h.p.l.c. procedures. The relationship between the retention parameters for... 

Winstead, C., 8c McKoy, V. (2006). Interaction of low-energy electrons with the purine bases, nucleosides, and nucleotides of DNA. The Journal of Chemical Physics, 125, 244302. 

C. Winstead and V. McKoy, J. Chem. Phys., 125, 244302 1-7 (2006). Interaction of Low-Energy Electrons with the Purine Bases, Nucleosides, and Nucleotides of DNA. 

Fig ire 2 shows the possible interconversions between purine bases, nucleosides and nucleoside monophosphates. Prom genetic and enzymatic studies it has been shown that the conversion of the free bases(adenine, hypoxanthine,xanthine and guanine) to the monophosphate level is carried out by at least three different enzymes (the phosphoribosyltransferases)(1,5). This is in contrast to htunan tissues, which have one specific adenine phosphoribosyltransferase and one transferase with activity towards hypoxanthine,xanthine and guanine. 

TABLE 1. INHIBITION OF NORMAL AND MUTANT HGPRT BY PURINE BASES, NUCLEOSIDES AND NUCLEOTIDES... 

Intact normal and HG-PRT deficient human erythrocytes were incubated in the presence of radioactively labeled purine bases, nucleosides and nucleotides, respectively. The uptake, interconversion and release of labeled compounds were studied by analysis of both medium and TCA supernatant of the red cells (cell content) by means of paper chromatography and high-voltage electrophoresis, followed by liquid scintillation counting. 

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