Purine 9- 3-amino-3-deoxy-5-0-

Decoyinine [6-amino- 9-(6-deoxy-jS-D-erythro-2-hex-5-enulofurano-syl)purine] 6-deoxy D ry7hro-2-hex-5-enulofuranose... 

S-ethyl-3-thio-D-xt/Zo isomer, and Raney nickel desulfurization of 6-amino-9- (2-first synthesis of a naturally occurring purine 2-deoxy-nucleoside to be reported. A number of nucleoside analogs were prepared by modification of the purine moiety before desulfurization. ... 

The yeast nucleoside containing a thio sugar has been shown to be 6-amino-9-(5-d-methyl-5-thio-D-ribofuranosyl)-9i/-purine []5-deoxy-5-(methyIthio)adenosine] (130). 

The two overwhelming oxidation products of the purine moiety of dGuo 37 arising from the transformation of guanine radical cations 38 were isolated and identified as 2,2-diamino-4-[(2-deoxy-/l-D-eryfhro-pentofura-nosyl)amino]-5(2H)-oxazolone (41) and its precursor 2-amino-5-[(2-deoxy-... 

Dimethylamino-9-(3/-amino-3,-deoxy-D-ribofuranosyl)-purine. J. Amer. chem. Soc. 77, 2396 (1955). 

The dialkoxyphosphinydifluoromethyllithium reagent has also been used in the preparation of bioactive compounds such as 2-amino-7,7-difluoro-7-phos-phonoheptanoic acid for evaluation in the -methyl-D-aspartic acid binding assay [265], 9-(5,5-difluoro-5-phosphonopentyl)quanine as a multisubstrate analog inhibitor of purine nucleoside phosphorylase [266], fluorinated phosphoserine analog [267, 268] (Scheme 91) and nucleoside 5 -deoxy-5 -di-fluoromethylphosphonates [267,269] (Scheme 92). 

Cl-IB-MECA l-[2-Chloro-6-[[(3-iodophenyl)methyl]amino]-9H-purin-p-yl]- 1-deoxy-N-methyl-beta-D-ribofuranuronamide... 

SYNS 2-AMINO-9-(2-DEOXY-P-d-RIBOFURANOSYL)-9H-PURINE-6-THIOL HYDRATE p-DEOXYTHIO-GUANOSINE P-2 -DEOXY-6-THIOGUANOSINE MONOHYDRATE D NSC-71261 DP-TGDR SAFETY PROFILE Poison by intravenous and intraperitoneal routes. Moderately toxic by ingesdon. Quesdonable carcinogen with experimental carcinogenic and neoplasdgenic data. When heated to decomposidon it emits very toxic fumes of NOx and SOx. 

AMINO-9-(2-DEOXY-p-d-RIBOFURANOSYL)-9H-PURINE-6-THIOL HYDRATE see TFJ250 4-AMINO-N-... 

N -[lsopalmitoylglycyl-4-amino-4-deoxy-L- glycero-L-glycoheptosyl]purine Septacidin (S. fimbriatus) B-70MI40900, p.256... 

A sugar derivative related to the purine nucleosides, namely methyl 5-(adenin-l-yl)-5-deoxy-2,3-0-isopropylidene-j8-D-ribofurano-side, is formed by the reaction of methyl 5-amino-5-deoxy-2,3-0-iso-propylidene-jS-D-ribofuranoside with l-benzyl-5-cyano-4[(ethoxy-methylene)amino]imidazole, followed by removal of the benzyl group. On fusion, this compound rearranges to methyl 5-deoxy-2,3-0-isopropylidene-5-[(purin-6-yl)amino]-/8-D-ribofuranoside, which can also be obtained from the reaction of methyl 5-amino-5-deoxy-2,3-0-isopropylidene-/8-D-ribofuranoside with 6-chloro-9-(tetrahydropyran-2-yl)purine. In the same manner, methyl 5-amino-5-deoxy-2,3-di-0-p-tolylsulfonyl-/3-D-ribofuranoside reacts with 6-chloro-9-(tetrahydro-pyran-2-yl)purine to give methyl 5-deoxy-5-[9-(tetrahydropyran-2-yl)-purin-6-yl]amino-2,3-di-0-p-tolylsulfonyl-j8-D-ribofuranoside. With liquid ammonia, 5 -0-p-tolylsulfonyladenosine gives 5 -amino-5 -deoxyadenosine. On heating in p-dioxane, ring closure to 3,5 -an-hydroadenosine is observed. ... 

In nucleotides, azides have been used for the introduction of amino groups into either the purine moiety, as in the synthesis of 8-aminoadenosine , or into the sugar moiety, as in the synthesis of 5-amino-5-deoxy uridine . 

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