Pupillary measures

Subjective effects of the experimental drugs were estimated from scores on several standardized tests and computer-delivered 100-mm visual analog scales that measured drug symptoms, strength and liking. The 100-mm scale was anchored with the terms not at all (0 mm) and extremely (100 mm). The subjects rated subjective effects at about the same times of the pupillary measures. 

The overall success rate for correct use of the pupillometer by participants (n = 37) was 92.9% that is, nearly every time participants attempted a trial they were eventually successful. The success rate (percentage obtaining a successful sequence on the first try of each study day) in participants after minimal experience (2 weeks or about 6 exposures) was 72%, and if the four participants who had trouble obtaining stability were eliminated, the overall success rate further increased to 81%. Thus, even minimally trained patients maintained on methadone4 or buprenorphine,16 drugs known to produce miosis, obtained reliable pupillary measures. 

Table 7.3 Comparison of Pupillary Measures in Participants (n = 4) with Urine Samples Consistently Negative for Illicit Drugs and Participants (n = 20) with Consistently Positive Urines...

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