Pulse radiolysis studies of indolyl radicals

Correlation of the chemical properties of the indolyl radicals from derivatives of indole-3-acetic acid failed to demonstrate clear structure/activity relationships for the peroxidase-catalysed cytotoxicity [159], and further work is required [160]. 

Space limitations mean that this article can present only an incomplete picture of the contributions of radiation chemistry in anti-cancer drug research. Nevertheless, it is hoped that both introductory discussion and specific examples will serve to illustrate the potential that radiation chemistry has in this area. 

This work is supported by the Cancer Research Campaign and the Gray Laboratory Cancer Research Trust. 

Wardman, Some applications of radiation chemistry to biochemistry and radiobiology, in Radiation Chemistry. Principles and Applications, Farhataziz and M.A.J. Rodgers (eds.), VCH Publishers, Deerfield Beach, 1987, p. 565. 

Doroshow and P. Hochstein, Redox cycling and the mechanism of action of antibiotics in neoplastic diseases, in Pathology of Oxygen, A.P. Autor (ed.). Academic Press, New York, 1982, p. 245. 

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