Pulmonary fibrosis murine models

Treatment with antibodies to CCRl led to a reduction in both inflammatory cell inflltrates and the development of flbrosis (80). Similar effects have been seen in murine model of obliterative bronchiolitis where the flbrotic response associated with this disorder was attenuated in CCR2 mice (65). This suggests that targeting chemokine receptors may be an efficient way to inhibit pulmonary fibrosis. 

Hu, C., Wang, Y., Fan, Y, Li, H., Wang, C., Zhang, J., Zhang, S., Han, X., Wen, C. (2015) Lipidomics revealed idiopathic pulmonary fibrosis-induced hepatic lipid disorders corrected with treatment of baicalin in a murine model. AAPS J. 17,711-722. 

Miyazaki Y, Araki K, Vesin C, Garcia 1, Kapanci Y, Whitsett JA, Piguet P-F, Vassalli P. Expression of a tumor necrosis fector-a transgene in murine lung causes lymphocytic andfibrosingalveohtis. A mouse model of progressive pulmonary fibrosis. J Clin Invest 1995 96 250-259. 

---