Pulmonary clearance

Fig. 4. Simplified rearrangement of the pulmonary clearance features of the kinetic model for retention and organ distribution of inhaled mCe.

Hirano, S., T. Shimada, J. Osugi, N. Kodama, and K.T. Suzuki. 1994. Pulmonary clearance and inflammatory potency of intratracheally instilled or acutely inhaled nickel sulfate in rats. Arch. Toxicol. 68 548-554. 

Evander E, Wollmer P, Jonson B, Lachmann B (1987) Pulmonary clearance of inhaled "mTc DTPA effects of surfactant depletion by lung lavage. J Appl Physiol 62 1611-1614. 

Wollmer P, Schainer W, Bos JA, Bakker W, Krenning EP, Lachmann B (1990) Pulmonary clearance of "mTC-DTPA during halothane anesthesia. Acta Anaes-thesiol Scand 34 572-575. 

Interaction with other biological surfactants might add to clearance and lipoplex inactivation. Size of the particles plays a major role because extensive microvasculature of the lung leads to pulmonary clearance of larger particles by capillary bed deposition. Vascularization was identified as the main... 

Nouri LA, Sordelli DO, Cerquetti MC, et al. 1983. Pulmonary clearance of Staphylococcus aureus and plasma angiotensin-converting enzyme activity in hydrocarbon pneumonitis. Pediatr Res 17(8) 657-661. 

Various studies have examined the incidence of gastric cancer with coal dust exposure because various carcinogenic substances have been identified in coal and because coal dust may reach the gastrointestinal tract through the pulmonary clearance system. Although... 

Animal studies have found that subchronic exposure to nuisance dusts at levels equal to the threshold limit value have induced mild inflammatory response in the lung and sufficient accumulation of particles to slow lung clearance. The investigators suggest that exposure to nuisance dust at a level that will impair pulmonary clearance should be avoided to prevent excessive accumulation of dust in the lung. 

Valentine R, Fisher GL. 1984. Pulmonary clearance of intratracheally administered iaSj in strain A/J mice. Environ Res 34 328-334. 

Cember H, Watson JA, Novak ME. 1961. The influence of radioactivity and lung burden on the pulmonary clearance rate of barium sulfate. Am Ind Hyg Assoc J 22 27-32. 

Acute Kerosene Mouse 20 ft L aspiration Pulmonary consolidation and hemorrhage, pneumonitis, decrease in pulmonary clearance of S. aureus, increase in relative lung weight, neurological effects including lack of coordination, drowsiness, behavioral changes Nourl el al. 1983... 

Bolton RE, Vincent JH, Jones AD, et al. 1983. An overload hypothesis for pulmonary clearance of UICC amosite fibres inhaled by rats. Br J Ind Med 40 264-272. 

Kuipers J A, Boer F, Olieman W et al 1999 First-pass lung uptake and pulmonary clearance of propofol assessment with a recirculatory indocyanine green pharmacokinetic model. Anesthesiology 91 1780-1787... 

Isopropanol is rapidly (within 30 min) and well absorbed ( 70% bioavailability) after oral administration. The Vj of isopropanol is 0.6-0.71 kg with minimal to no protein binding. Isopropanol is rapidly metabolized by alcohol dehydrogenase in a first-order, concentration-dependent manner to acetone. This apparent first-order metabolism of isopropanol is probably a result of extensive pulmonary clearance of the acetone. Approximately 80% of systemic isopropanol is metabolized to acetone with the remainder excreted unchanged via the kidneys. A very small amount of isopropanol may be eliminated via the lungs. The presence of ethanol will competitively... 

Walker PS, Conway JH, Fleming JS, Bondesson E, Borgstrom L. Pulmonary clearance rate of two chemically different forms of inhaled pertechnetate. J Aerosol Med 2001 14(2) 209-215. 

Indirect evidence of absorption after inhalation of vanadium in animals is indicated in studies in which vanadium was administered intratracheally. Soluble vanadium compounds that are inhaled and deposited are readily absorbed. Initial pulmonary clearance is rapid in rats. There was rapid 100% absorption of vanadium in rats receiving radiolabeled vanadyl chloride (Conklin et al. 1982). 

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